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Updated: May 21, 2026

Amide Coupling Reaction for the Synthesis of Bispyridine-based Ligands and Their Complexation to Platinum as Dinuclear Anticancer Agents
Published on: May 28, 2014
STATing the importance of immune modulation by platinum chemotherapeutics
Stanleyson V Hato1, I Jolanda M de Vries, W Joost Lesterhuis
1Department of Tumor Immunology; Radboud University Medical Centre and Nijmegen Centre for Molecular Life Sciences; Nijmegen, The Netherlands.
Abstract:
Platinum-based anticancer drugs enhance the immunostimulatory potential of DCs and decrease the immunosuppressive capacity of tumor cells. This immunomodulatory ability is based on the inhibition of STAT6-mediated expression of co-inhibitory molecule PD-L2 and opens up the possibility of using these drugs in combination with other immunostimulatory compounds.
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