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Updated: May 21, 2026

A Heterotopic Mouse Model for Studying Laryngeal Transplantation
Published on: January 13, 2023
Aortic homograft reconstruction of partial laryngectomy defects: a new technique
Steven M Zeitels1, John C Wain, Anca M Barbu
1Department of Surgery, Harvard Medical School, Center for Laryngeal Surgery and Voice Rehabilitation Boston, Massachusetts 02114, USA.
Objectives:
Wide-field transcervical partial laryngectomy often precludes tracheotomy decannulation. It is done infrequently today, primarily because of the popularity of chemotherapy-radiotherapy treatment regimens and limited enthusiasm for using transcervical partial laryngectomy after failed radiotherapy. We sought to identify a new reconstructive technique that would provide an alternative to total laryngectomy in as many patients as possible.
Methods:
We performed a retrospective examination of 15 patients who underwent single-stage wide-field transcervical partial laryngectomy with cryopreserved aortic homograft reconstruction. Eight of the 15 patients had previously undergone failed radiotherapy. At least 40% of the cricoid circumference was resected in 8 patients.
Results:
All 15 patients had their tracheotomy tube removed and have laryngeal phonation, and 14 of the 15 resumed oral intake. There were no major surgical complications.
Conclusions:
Use of aortic homografts is a new, reliable, and versatile reconstructive option for performing conservation laryngeal cancer surgery that allows for airway, swallowing, and voice preservation.

