Golgi complex fragmentation in G2/M transition: An organelle-based cell-cycle checkpoint
Daniela Corda1, Maria Luisa Barretta, Romina Ines Cervigni
1Institute of Protein Biochemistry, National Research Council (CNR), Via Pietro Castellino 111, Naples, Italy. d.corda@ibp.cnr.it
IUBMB Life
|June 26, 2012
Summary
Mammalian cells disassemble the Golgi ribbon during mitosis for proper inheritance. Disrupting this process halts cell division, indicating a Golgi mitotic checkpoint monitors Golgi complex partitioning.
Area of Science:
- Cell Biology
- Molecular Biology
- Cell Cycle Regulation
Background:
- The Golgi complex in mammalian cells forms a continuous Golgi ribbon, crucial for cell function.
- During mitosis, this ribbon fragments for accurate partitioning into daughter cells.
- Inhibition of Golgi disassembly causes cell-cycle arrest, suggesting a monitoring mechanism.
Purpose of the Study:
- To discuss the mechanisms regulating Golgi ribbon breakdown during mitosis.
- To explore how Golgi partitioning influences the G2/M cell-cycle transition.
- To highlight the role of the Golgi mitotic checkpoint.
Main Methods:
- Literature review and discussion of existing research on Golgi ribbon dynamics.
- Analysis of cell-cycle progression in relation to Golgi complex fragmentation.
- Exploration of regulatory pathways involved in Golgi disassembly.
Main Results:
- Golgi ribbon fragmentation is a multistage process essential for cell division.
- Inhibition of Golgi disassembly leads to G2 cell-cycle arrest.
- A Golgi mitotic checkpoint likely ensures accurate Golgi inheritance.
Conclusions:
- The Golgi ribbon undergoes regulated breakdown during mitosis.
- Accurate partitioning of the Golgi complex is monitored by a cell-cycle checkpoint.
- Understanding Golgi dynamics is key to comprehending cell division regulation.
Related Concept Videos
01:28The Cell Cycle Control System
The cell cycle regulation directs how a cell proceeds from one phase to the next and begins mitosis. The cell cycle control system includes intracellular regulatory molecules and external triggers. They provide "stop" or "advance" signals and operate at specific cell cycle stages termed checkpoints to ensure that a particular process is completed before the cell advances to the next phase.
Cyclins and cyclin-dependent kinases (Cdks) are the primary cell cycle regulators and function at the cell...
Cyclins and cyclin-dependent kinases (Cdks) are the primary cell cycle regulators and function at the cell...
02:11The Cell Cycle Control System
The cell cycle is an organized set of events that leads the cell to divide into two daughter cells, each containing chromosomes identical to the parent cell. It is the cell cycle that leads to the formation of an entire organism from a single-cell zygote. Besides, cell division also functions in the renewal or repair of tissues in adult multicellular eukaryotes. For example, in the bone marrow, the stem cells divide to form new blood cells. Although essential for several functions, cell...
02:11The Cell Cycle Control System
The cell cycle is an organized set of events that leads the cell to divide into two daughter cells, each containing chromosomes identical to the parent cell. It is the cell cycle that leads to the formation of an entire organism from a single-cell zygote. Besides, cell division also functions in the renewal or repair of tissues in adult multicellular eukaryotes. For example, in the bone marrow, the stem cells divide to form new blood cells. Although essential for several functions, cell...
02:19The Spindle Assembly Checkpoint
The spindle assembly checkpoint is a molecular surveillance mechanism ensuring the fidelity of chromosome segregation during anaphase. The checkpoint monitors the completion of all the prerequisite steps before chromosome segregation to determine whether the segregation process should proceed or be delayed.
Many proteins function together to control the spindle assembly checkpoint. Mutations affecting these proteins may allow cells to proceed into anaphase prematurely, resulting in the...
Many proteins function together to control the spindle assembly checkpoint. Mutations affecting these proteins may allow cells to proceed into anaphase prematurely, resulting in the...
02:19The Spindle Assembly Checkpoint
The spindle assembly checkpoint is a molecular surveillance mechanism ensuring the fidelity of chromosome segregation during anaphase. The checkpoint monitors the completion of all the prerequisite steps before chromosome segregation to determine whether the segregation process should proceed or be delayed.
Many proteins function together to control the spindle assembly checkpoint. Mutations affecting these proteins may allow cells to proceed into anaphase prematurely, resulting in the...
Many proteins function together to control the spindle assembly checkpoint. Mutations affecting these proteins may allow cells to proceed into anaphase prematurely, resulting in the...
02:15M-Cdk Drives Transition Into Mitosis
Checkpoints throughout the cell cycle serve as safeguards and gatekeepers, allowing the cell cycle to progress in favorable conditions and slow or halt it in problematic ones. This regulation is known as the cell cycle control system.
Cyclin-dependent kinases, or Cdks, work in concert with cyclins to control cell cycle transitions. M-Cdk, a complex of Cdk1 bound to M cyclin, is a well-known example of this coordinated control that drives the transition from the G2 to the M phase.
M cyclin...
Cyclin-dependent kinases, or Cdks, work in concert with cyclins to control cell cycle transitions. M-Cdk, a complex of Cdk1 bound to M cyclin, is a well-known example of this coordinated control that drives the transition from the G2 to the M phase.
M cyclin...