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Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...

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Related Experiment Video

Updated: May 21, 2026

Human Ex vivo Wound Model and Whole-Mount Staining Approach to Accurately Evaluate Skin Repair

Human Ex vivo Wound Model and Whole-Mount Staining Approach to Accurately Evaluate Skin Repair

Published on: February 17, 2021

Age-related skin changes.

Aleksandra Levakov¹, Nada Vucković, Matilda Dolai

¹Center for Pathology and Histology, Clinical Center of Vojvodina, Novi Sad. aleksandralevakov@sbb.rs

Medicinski Pregled

|June 27, 2012

Summary

Skin aging involves changes like fat reduction and dermal damage from sun exposure. Older skin shows thinner epidermis, more granules, flattened junctions, and reduced elasticity due to altered fibroblast function.

Related Experiment Videos

Last Updated: May 21, 2026

Human Ex vivo Wound Model and Whole-Mount Staining Approach to Accurately Evaluate Skin Repair

Human Ex vivo Wound Model and Whole-Mount Staining Approach to Accurately Evaluate Skin Repair

Published on: February 17, 2021

Area of Science:

Dermatology
Gerontology
Cell Biology

Background:

Skin aging is a complex process influenced by intrinsic (chronological) and extrinsic (photo-aging) factors.
These factors lead to visible changes such as wrinkles, sagging, and textural alterations.

Purpose of the Study:

To investigate and compare the histological changes in sun-exposed versus sun-protected skin across a wide age range.
To elucidate the structural and cellular modifications associated with chronological and photo-induced skin aging.

Main Methods:

Analysis of 45 skin biopsy samples from both sun-exposed and sun-protected areas.
Histological examination to assess epidermal thickness, cellular layers, keratohyaline granules, dermoepidermal junction, dermal elastotic material, inflammatory infiltrate, fibrous trabeculae, and hypodermal thickness.

Main Results:

Younger skin exhibits greater epidermal thickness and more cellular layers.
Older skin shows increased keratohyaline granules, flattened dermoepidermal junction, pronounced dermal elastotic material, and thickened fibrous trabeculae.
Significant atrophy of the hypodermis and reduced skin elasticity were observed with age, linked to diminished fibroblast lifespan and collagen production.

Conclusions:

Both chronological aging and photo-aging induce distinct and cumulative changes in skin structure.
Understanding these age-related histological alterations is crucial for developing effective anti-aging and skin rejuvenation strategies.