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Related Concept Videos

Aortic Regurgitation III: Medical Management01:25

Aortic Regurgitation III: Medical Management

Aortic regurgitation (AR) is when the aortic valve does not close or seal properly, leading to backward blood circulation from the aorta into the left ventricle during diastole. Common causes of AR include rheumatic heart disease, congenital valve defects, and aortic root dilation. Managing AR requires a multifaceted approach to alleviate symptoms, preserve left ventricular function, and address the underlying cause of the regurgitation. Patients with symptomatic AR or significant left...
Aortic Regurgitation I: Introduction01:15

Aortic Regurgitation I: Introduction

IntroductionAortic regurgitation is characterized by the backward flow of blood from the aorta into the left ventricle during diastole and arises from the improper closure of the aortic valve. This condition results in left ventricular volume overload and can stem from both acute and chronic etiologies, each contributing uniquely to the disease's progression and symptomatology.Acute and Chronic CausesAcute aortic regurgitation often results from events that suddenly impair the integrity of the...

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Related Experiment Video

Updated: May 21, 2026

Upper-extremity Approach for Secondary Access in Transfemoral Transcatheter Aortic Valve Implantation
06:04

Upper-extremity Approach for Secondary Access in Transfemoral Transcatheter Aortic Valve Implantation

Published on: August 8, 2025

Transcatheter aortic valve replacement: design, clinical application, and future challenges.

John K Forrest1

  • 1Yale School of Medicine, New Haven, CT 06519, USA. john.k.forrest@yale.edu

The Yale Journal of Biology and Medicine
|June 28, 2012
PubMed
Summary

Transcatheter aortic valve replacement (TAVR) offers improved survival for severe aortic stenosis patients ineligible for surgery. This review examines TAVR technology, clinical outcomes, and future therapeutic challenges.

Keywords:
Edwards Sapien ValveMedtronic CoreValveTAVITAVRtranscatheter aortic valve replacement

Related Experiment Videos

Last Updated: May 21, 2026

Upper-extremity Approach for Secondary Access in Transfemoral Transcatheter Aortic Valve Implantation
06:04

Upper-extremity Approach for Secondary Access in Transfemoral Transcatheter Aortic Valve Implantation

Published on: August 8, 2025

Area of Science:

  • Cardiovascular Medicine
  • Interventional Cardiology
  • Biomedical Engineering

Background:

  • Severe symptomatic aortic stenosis poses significant risks, especially for patients unsuitable for traditional surgery.
  • Transcatheter aortic valve replacement (TAVR) has emerged as a viable alternative, improving patient survival and quality of life.
  • The U.S. FDA has approved TAVR for specific patient populations, marking a significant advancement in cardiac care.

Purpose of the Study:

  • To review the historical development and design evolution of transcatheter aortic valves.
  • To analyze published clinical results and outcomes of TAVR procedures.
  • To explore future directions and challenges in transcatheter valve therapeutics.

Main Methods:

  • Review of scientific literature and clinical trial data on TAVR.
  • Comparative analysis of currently available transcatheter valves (Edwards Sapien, Medtronic CoreValve).
  • Examination of technological advancements in transcatheter valve design and delivery systems.

Main Results:

  • TAVR has demonstrated improved survival rates and quality of life in selected patients with severe aortic stenosis.
  • Available transcatheter valves, while sharing similarities, possess distinct design features impacting delivery and patient performance.
  • Ongoing research and development continue to refine TAVR technology.

Conclusions:

  • TAVR represents a significant therapeutic option for patients with severe aortic stenosis who are not candidates for conventional surgery.
  • Understanding the nuances of different TAVR devices is crucial for optimizing patient outcomes.
  • The field of transcatheter valve therapeutics holds promise for future advancements in cardiovascular medicine.