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Updated: May 21, 2026

An Oncogenic Hepatocyte-Induced Orthotopic Mouse Model of Hepatocellular Cancer Arising in the Setting of Hepatic Inflammation and Fibrosis
Published on: September 12, 2019
Immune surveillance of pre-cancerous senescent hepatocytes limits hepatocellular carcinoma development
Tetyana Yevsa1, Tae-Won Kang, Lars Zender
1Helmholtz Centre for Infection Research; Braunschweig, Germany ; Hannover Medical School; Department of Gastroenterology, Hepatology and Endocrinology; Hannover, Germany.
Abstract:
Here we discuss a recently published study from our group on how a continuous CD4 T-cell dependent immune clearance of premalignant senescent cells, designated "senescence surveillance," restricts liver cancer development.
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