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Published on: March 28, 2017
Effective cytochrome P450 (CYP) inhibitors isolated from tarragon (Artemisia dracunculus)
Zeineb Brahmi1, Tatsuya Katho, Rie Hatsumata
1Department of Nutritional Science, Faculty of Applied Bio-Science, Tokyo University of Agriculture, Japan.
Abstract:
Two effective cytochrome P450 (CYP) inhibitors were isolated from tarragon, Artemisia dracunculus. Their structures were spectroscopically identified as 2E,4E-undeca-2,4-diene-8,10-diynoic acid isobutylamide (1) and 2E,4E-undeca-2,4-diene-8,10-diynoic acid piperidide (2). Both compounds had dose-dependent inhibitory effects on CYP3A4 activity with IC50 values of 10.0 ± 1.3 µM for compound 1 and 3.3 ± 0.2 µM for compound 2, and exhibited mechanism-based inhibition. This is the first reported isolation of effective CYP inhibitors from tarragon (Artemisia dracunculus) purchased from a Japanese market.
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