Related Experiment Video
Updated: May 21, 2026
06:01
A Genetically Engineered Mouse Model of Sporadic Colorectal Cancer
Published on: July 6, 2017
Priceless GEMMs: genetically engineered mouse models for colorectal cancer drug development
1Gastroenterology Division, Department of Medicine, Tufts Medical Center, Boston, MA 02111, USA.
Trends in Pharmacological Sciences
|June 29, 2012
Summary
Preclinical mouse models, including xenografts and genetically engineered mouse models (GEMMs), are vital for effective colorectal cancer (CRC) drug development. Newer GEMMs and advanced imaging enhance in vivo tumor assessment for translational research.
Area of Science:
- Oncology
- Translational Medicine
- Preclinical Research
Background:
- Effective drug development for colorectal cancer (CRC) requires robust preclinical models.
- Mouse models offer advantages in cost, lifespan, and usability for CRC research.
- Two main categories exist: xenografts and genetically engineered mouse models (GEMMs).
Purpose of the Study:
- To review xenografts and GEMMs for colorectal cancer (CRC) and their translational applications.
- To highlight newer GEMMs suitable for sporadic CRC drug testing.
- To discuss advances in small-animal imaging for in vivo tumor assessment.
Main Methods:
- Review of existing literature on mouse models for colorectal cancer (CRC).
- Focus on xenografts and genetically engineered mouse models (GEMMs).
- Discussion of small-animal imaging techniques like optical colonoscopy.
Main Results:
- Xenografts and GEMMs serve as key preclinical models for CRC.
- Newer GEMMs show particular promise for drug testing in sporadic CRC.
- Small-animal imaging enables in vivo tumor evaluation.
Conclusions:
- Sophisticated GEMMs and imaging technologies are advancing CRC preclinical research.
- These models offer significant potential for effective colorectal cancer drug development.
- Preclinical advancements provide renewed hope in combating colorectal cancer.
Related Concept Videos
02:43Mouse Models of Cancer Study
Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...
02:43Mouse Models of Cancer Study
Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...