Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Type II Diabetes I: Introduction

Type II Diabetes I: Introduction

Type 2 diabetes mellitus (T2DM) is a chronic metabolic disorder characterized by insulin resistance, in which target tissues such as the liver, muscle, and adipose tissue respond poorly to insulin. It is also associated with inadequate compensatory insulin secretion, where pancreatic β-cells fail to produce sufficient insulin. Together, these abnormalities lead to persistent hyperglycemia.EtiologyT2DM develops through a complex interaction of genetic predisposition and environmental or...

Type II Diabetes II: Pathophysiology

Type II Diabetes II: Pathophysiology

PathophysiologyType 2 diabetes mellitus (T2DM ) is a chronic metabolic disorder characterized by insulin resistance and progressive pancreatic β-cell dysfunction, leading to impaired glucose homeostasis. It results from interactions among genetic predisposition, environmental factors, and metabolic stressors, such as overnutrition and a sedentary lifestyle.Insulin Resistance and Glucose DysregulationEarly T2DM involves insulin resistance in skeletal muscle, adipose tissue, and the liver.

Diabetes Mellitus: Type 2 and Gestational

Diabetes Mellitus: Type 2 and Gestational

Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...

Type II Diabetes Mellitus III: Clinical Manifestations and Diagnosis

Type II Diabetes Mellitus III: Clinical Manifestations and Diagnosis

Type 2 diabetes mellitus develops gradually and is often asymptomatic in early stages.Clinical ManifestationsWhen symptoms appear, they include fatigue, blurred vision, pruritus, delayed wound healing, and recurrent infections, particularly candidal infections. Peripheral neuropathy may present as numbness or tingling in the extremities. Classic hyperglycemia symptoms—polyuria, polydipsia, and polyphagia—are less common. Most patients are overweight and frequently have associated hypertension...

Diabetes Mellitus: Overview and Type I Subtype

Diabetes Mellitus: Overview and Type I Subtype

Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...

Type I Diabetes II: Pathophysiology

Type I Diabetes II: Pathophysiology

Type 1 diabetes mellitus arises from an immune-mediated destruction of pancreatic β-cells, resulting in an absolute deficiency of insulin. This process develops in genetically susceptible individuals when autoimmunity, environmental exposures, and immunologic dysregulation converge to trigger a targeted attack on the insulin-producing cells of the pancreas. The β-cells are located within the islets of Langerhans and are essential for regulating blood glucose by facilitating cellular uptake of...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Update on the American Diabetes Association Standards of Medical Care.

The Nurse practitioner·2014

Same author

Overweight and obesity: pharmacotherapeutic considerations.

Journal of the American Academy of Nurse Practitioners·2011

Same author

The relationship among registered nurses' weight status, weight loss regimens, and successful or unsuccessful weight loss.

Journal of the American Academy of Nurse Practitioners·2011

Same author

How NONPF has helped shape NP education.

The Nurse practitioner·2010

Same author

Take chest pain to heart.

The Nurse practitioner·2010

Same author

Evaluation of the acute abdomen. Key issues in primary care settings.

Advance for nurse practitioners·2009

Search research articles

Related Experiment Video

Updated: May 21, 2026

A Zebrafish Model of Diabetes Mellitus and Metabolic Memory

A Zebrafish Model of Diabetes Mellitus and Metabolic Memory

Published on: February 28, 2013

Type 2 diabetes mellitus: an evidence-based update.

Bruce S Zitkus¹

¹Family Nurse Practitioner Program Department at the School of Health Professions & Nursing at Long Island University in Brookville, NY, USA.

The Nurse Practitioner

|June 29, 2012

Summary

This review offers primary care clinicians practical strategies for managing type 2 diabetes mellitus (T2DM) based on the latest evidence-based guidelines. It aims to improve clinical decision-making for adults diagnosed with T2DM.

Related Experiment Videos

Last Updated: May 21, 2026

A Zebrafish Model of Diabetes Mellitus and Metabolic Memory

A Zebrafish Model of Diabetes Mellitus and Metabolic Memory

Published on: February 28, 2013

Area of Science:

Endocrinology
Primary Care Medicine
Diabetes Management

Background:

Clinical management of type 2 diabetes mellitus (T2DM) presents ongoing challenges in primary care settings.
Both novice and experienced clinicians require updated guidance for effective T2DM patient care.

Purpose of the Study:

To review the most recent evidence-based guidelines for T2DM management.
To provide practical strategies for integrating these guidelines into primary care.

Main Methods:

Literature review of current clinical practice guidelines for T2DM.
Synthesis of evidence to support primary care application.

Main Results:

The article consolidates key recommendations from leading T2DM guidelines.
It highlights actionable steps for primary care physicians.

Conclusions:

Effective T2DM management in primary care is achievable with updated guideline implementation.
This review supports enhanced clinical decision-making for T2DM patients.