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Doppler Optical Coherence Tomography of Retinal Circulation
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Published on: September 18, 2012

Doppler-based lateral motion tracking for optical coherence tomography.

Nicolás Weiss1, Ton G van Leeuwen, Jeroen Kalkman

  • 1Biomedical Engineering & Physics, Academic Medical Center, University of Amsterdam, PO Box 22700, 1100 DE Amsterdam, The Netherlands. n.m.weiss@amc.uva.nl

Optics Letters
|June 29, 2012
PubMed
Summary
This summary is machine-generated.

Nonuniform scanning in optical coherence tomography causes artifacts. This study introduces a Doppler shift-based solution for accurate imaging and flow velocity measurements, enabling in vivo skin imaging.

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Area of Science:

  • Biomedical Optics
  • Medical Imaging
  • Flowmetry

Background:

  • Nonuniform lateral scanning in optical coherence tomography (OCT) introduces imaging artifacts.
  • These artifacts result in morphologically inaccurate sample representations, hindering diagnostic capabilities.

Purpose of the Study:

  • To address artifacts caused by nonuniform lateral scanning in OCT.
  • To enable accurate morphological representation and Doppler flow velocity measurements.
  • To demonstrate the feasibility of hand-held, large-area in vivo OCT imaging.

Main Methods:

  • Utilizing the Doppler shift within the complex-valued depth-resolved scattering amplitude.
  • Implementing lateral scanning with arbitrary and varying velocities over large surfaces.
  • Performing centimeters-long hand-held B-mode imaging of skin in vivo.

Main Results:

  • Successfully corrected imaging artifacts caused by nonuniform lateral scanning.
  • Achieved accurate morphological representation of the sample.
  • Demonstrated feasible Doppler flow velocity measurements in underlying flow channels.
  • Successfully performed centimeters-long hand-held B-mode imaging of skin in vivo.

Conclusions:

  • The Doppler shift-based approach effectively corrects OCT artifacts from nonuniform scanning.
  • This method enables accurate in vivo flow velocity assessment and large-area imaging.
  • The technique holds promise for advanced non-invasive biomedical imaging applications.