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Related Concept Videos

Computed Tomography01:10

Computed Tomography

Tomography refers to imaging by sections. Computed tomography (CT) is a non-invasive imaging technique that uses computers to analyze several cross-sectional X-rays to reveal minute details about structures in the body.
The technique was invented in the 1970s and is based on the principle that as X-rays pass through the body, they are absorbed or reflected at different levels. In the technique, a patient lies on a motorized platform while a computerized axial tomography (CAT) scanner rotates...
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Ultrasound II: Endoscopic Ultrasound and FibroScan

Endoscopic Ultrasound (EUS) and FibroScan are valuable diagnostic tools in gastroenterology and hepatology, each with specific applications and techniques.
Endoscopic Ultrasound (EUS):
Imaging Studies III: Computed Tomography01:27

Imaging Studies III: Computed Tomography

DefinitionComputed Tomography (CT) of the genitourinary (GU) tract is a non-invasive imaging modality that utilizes X-rays and computer processing to generate detailed cross-sectional images of the urinary system, encompassing the kidneys, ureters, bladder, and adjacent structures such as the adrenal glands.PurposeCT scans of the GU tract serve several diagnostic and therapeutic purposes, including:Diagnosis of Urinary Tract Diseases: Detects kidney stones, tumors, cysts, and congenital...
Imaging Biological Samples with Optical Microscopy01:18

Imaging Biological Samples with Optical Microscopy

Optical microscopy uses optic principles to provide detailed images of samples. Antonie van Leeuwenhoek designed the first compound optical microscope in the 17th century to visualize blood cells, bacteria, and yeast cells. In 1830, Joseph Jackson Lister created an essentially modern light microscope. The 20th century saw the development of microscopes with enhanced magnification and resolution.
In optical microscopy, the specimen to be viewed is placed on a glass slide and clipped on the stage...
Ultrasonography01:17

Ultrasonography

Ultrasonography is an imaging technique that uses high-frequency sound waves to visualize the body's internal structures. It is a non-invasive and safe procedure that does not involve the use of ionizing radiation, making it widely used in various medical fields. Ultrasonography is used to study heart function, blood flow in the neck or extremities, certain conditions such as gallbladder disease, and fetal growth and development.
During an ultrasonography procedure, a handheld device called a...
Positron Emission Tomography01:29

Positron Emission Tomography

Positron emission tomography (PET) is a medical imaging technique involving radiopharmaceuticals — substances that emit short-lived radiation. Although the first PET scanner was introduced in 1961, it took 15 more years before radiopharmaceuticals were combined with the technique and revolutionized its potential.
One of the main requirements of a PET scan is a positron-emitting radioisotope, which is produced in a cyclotron and then attached to a substance used by the part of the body being...

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Related Experiment Video

Updated: May 21, 2026

In Vivo, Percutaneous, Needle Based, Optical Coherence Tomography of Renal Masses
09:31

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Published on: March 30, 2015

Real-time three-dimensional optical coherence tomography image-guided core-needle biopsy system.

Wei-Cheng Kuo, Jongsik Kim, Nathan D Shemonski

    Biomedical Optics Express
    |June 29, 2012
    PubMed
    Summary

    This study introduces an integrated core-needle biopsy system using 3D optical coherence tomography (OCT) for real-time guidance. This novel approach enhances tissue imaging and assessment during biopsy procedures.

    Keywords:
    (110.6880) Three-dimensional image acquisition(120.3890) Medical optics instrumentation(170.1610) Clinical applications(170.4500) Optical coherence tomography

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    Published on: November 4, 2014

    Area of Science:

    • Biomedical Engineering
    • Medical Imaging
    • Optical Coherence Tomography

    Background:

    • Current image-guided biopsies (ultrasound, CT) face limitations in spatial or temporal resolution.
    • Optical coherence tomography (OCT) offers high-resolution, real-time tissue imaging.
    • Integrating OCT into biopsy needles is a promising but underdeveloped approach.

    Purpose of the Study:

    • To develop and demonstrate an integrated core-needle biopsy system with 3D OCT for real-time image guidance.
    • To enable precise target tissue localization and imaging prior to biopsy.
    • To assess biopsied specimens immediately at the point-of-care.

    Main Methods:

    • Development of a catheter-based 3D OCT system integrated within a core-needle device.
    • Real-time OCT imaging for guiding needle placement and visualizing tissue.
    • Acquisition and correlation of OCT images with histology for ex vivo tumor specimens.
    • Computational visualization of 3D OCT volumes for specimen assessment.

    Main Results:

    • Successful demonstration of an integrated 3D OCT and core-needle biopsy system.
    • Real-time OCT imaging provided guidance for target localization and pre-biopsy tissue imaging.
    • OCT imaging of biopsied specimens correlated well with histology.
    • 3D OCT visualization offered feedback on specimen type and biopsy quality.

    Conclusions:

    • The integrated system shows potential for OCT-guided needle biopsies.
    • Real-time, in-needle OCT imaging can improve biopsy accuracy and specimen assessment.
    • This technology could advance minimally invasive diagnostic procedures.