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Updated: May 21, 2026

A Syngeneic Mouse Model of Metastatic Renal Cell Carcinoma for Quantitative and Longitudinal Assessment of Preclinical Therapies
06:38

A Syngeneic Mouse Model of Metastatic Renal Cell Carcinoma for Quantitative and Longitudinal Assessment of Preclinical Therapies

Published on: April 12, 2017

Novel molecular targets for the therapy of renal cell carcinoma

Aymen A Elfiky1, Guru Sonpavde

  • 1Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02215, USA.

Discovery Medicine
|June 30, 2012
PubMed

Insights

The treatment of metastatic renal cell carcinoma (mRCC) has shifted from cytokine therapy to targeted and antiangiogenic agents. Future developments in vaccines and immunotherapies offer new hope for improving patient outcomes.

Area of Science:

  • Oncology
  • Immunology

Background:

  • Historically, cytokine-based therapies dominated renal cancer treatment.
  • Recent years show a significant shift in therapeutic strategies for metastatic renal cell carcinoma (mRCC).

Purpose of the Study:

  • To review the evolving therapeutic landscape of mRCC.
  • To highlight emerging treatment modalities beyond current standards.

Main Methods:

  • Literature review of recent advancements in renal cancer therapy.
  • Analysis of the impact of targeted and antiangiogenic agents.

Main Results:

  • Molecularly targeted and antiangiogenic agents are now standard for mRCC.
  • These agents represent a paradigm shift from previous cytokine-based approaches.

Conclusions:

  • While major shifts may stabilize, novel approaches like vaccines and immunotherapies are under development.
  • These emerging therapies hold promise for enhanced therapeutic outcomes in mRCC patients.

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The Use of Reverse Phase Protein Arrays (RPPA) to Explore Protein Expression Variation within Individual Renal Cell Cancers12:22

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