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Related Concept Videos

Antiasthma Drugs: Inhaled Corticosteroids and Glucocorticoids01:25

Antiasthma Drugs: Inhaled Corticosteroids and Glucocorticoids

Inhaled corticosteroids (ICS) are anti-inflammatory drugs used primarily in treating persistent asthma and providing long-term maintenance. They target the bronchial mucosa, the lining of the airways, to control inflammation, a critical factor in asthma progression and exacerbation.
ICS work through a multifaceted mechanism of action. They suppress the inflammatory response caused by the proliferation of TH cells. They also reduce the transcription of the IL-2 gene, which is involved in the...
COPD: Management Using Bronchodilators and Corticosteroids01:26

COPD: Management Using Bronchodilators and Corticosteroids

Chronic obstructive pulmonary isease (COPD) involves a group of progressive lung disorders characterized by persistent airflow limitation and chronic respiratory symptoms. Asthma-COPD Overlap Syndrome (ACOS), encompassing features of both asthma and Chronic obstructive pulmonary disease (COPD), is a group of progressive lung disorders that includes chronic bronchitis, emphysema, and refractory (non-reversible) asthma. ACOS leads to complex clinical presentations that combine the inflammatory...
Inhaled Medications01:23

Inhaled Medications

Inhaled medications are crucial for managing chronic obstructive pulmonary disease (COPD) and asthma. They are essential for effective treatment and control, ensuring optimal respiratory health and well-being. Inhaled medication delivers drugs directly to the lungs, providing a rapid onset of action and reducing systemic side effects compared to oral or injectable medications. Three primary types of inhalation devices are used to administer these medications: nebulizers, metered-dose inhalers...
Drugs Used in Lower Respiratory Disorders: Overview01:17

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Lower respiratory tract disorders present challenges that often require skilled and nuanced approaches for effective management. Common ailments, such as asthma and chronic obstructive pulmonary disease (COPD), have prompted the development of intricate treatment strategies involving bronchodilators and anti-inflammatory drugs, each tailored to ease breathing and revitalize the lungs.
Bronchodilators, the first step of respiration enhancement, come in various forms, each with its own mechanism...
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Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
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Clinical Assessment for Asthma:
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Related Experiment Video

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Dry Powder and Nebulized Aerosol Inhalation of Pharmaceuticals Delivered to Mice Using a Nose-only Exposure System
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[Inhaled corticosteroids and behavioural changes in children].

Nancy Broos1, Tjalling W de Vries, Eric J Duiverman

  • 1Universitair Medisch Centrum, afd. Klinische Farmacie, Utrecht, the Netherlands. nancybroos@hotmail.com

Nederlands Tijdschrift Voor Geneeskunde
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Summary

Inhaled corticosteroids can cause behavioral changes like aggression and mood swings in children. Early recognition of these side effects is crucial for proper management and to avoid unnecessary medical tests.

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Area of Science:

  • Pediatric medicine
  • Pharmacology

Background:

  • Inhaled corticosteroids (ICS) are a common treatment for pediatric respiratory conditions.
  • Adverse drug reactions, including behavioral changes, can occur with ICS use.

Observation:

  • Two pediatric patients, a 7-year-old boy and a 9-year-old girl, exhibited behavioral changes.
  • These changes included hyperactivity, aggression, mood swings, and agitation.

Findings:

  • The observed behavioral changes were linked to the use of inhaled corticosteroids.
  • These side effects are reversible upon recognition and potential adjustment of treatment.

Implications:

  • Timely recognition of ICS-induced behavioral changes is essential in pediatric care.
  • Awareness can prevent misdiagnosis, unnecessary investigations, and psychosocial problems for children.
  • Healthcare providers should consider behavioral side effects when prescribing inhaled corticosteroids to children.