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Related Experiment Video

Updated: Jan 6, 2026

Mouse Body Temperature Measurement Using Infrared Thermometer During Passive Systemic Anaphylaxis and Food Allergy Evaluation

Mouse Body Temperature Measurement Using Infrared Thermometer During Passive Systemic Anaphylaxis and Food Allergy Evaluation

Published on: September 14, 2018

TauroSept-Induced Anaphylaxis: A Pediatric Case Report.

Elise Mank¹, Nancy Broos², Ingrid Terreehorst³

¹Department of Pediatrics, Emma Children's Hospital, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands.

Pediatric Allergy, Immunology, and Pulmonology

|September 11, 2025

Summary

TauroSept®, a taurolidine lock solution, is generally safe for children receiving parenteral nutrition. However, this case highlights a rare instance of anaphylaxis in an infant, emphasizing the need for clinical awareness of potential side effects.

Keywords:

TauroSept allergic reaction anaphylaxis children povidone taurolidine

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Published on: December 15, 2011

Area of Science:

Pediatric Gastroenterology
Clinical Pharmacology

Background:

Children with intestinal failure require parenteral nutrition via central venous catheters, increasing their risk of catheter-related bloodstream infections.
Taurolidine lock solutions have been widely used for prophylaxis against these infections and are generally considered safe in pediatric populations.

Purpose of the Study:

To report the first documented case of anaphylaxis in an infant following the administration of TauroSept® (taurolidine).

Main Methods:

A case report detailing a 1-month-old infant with jejunal atresia receiving parenteral nutrition.
Observation of adverse events, including circulatory insufficiency and angioedema, shortly after TauroSept® administration.
Measurement of serum tryptase levels to assess for anaphylaxis.

Main Results:

The infant developed severe symptoms consistent with anaphylaxis after TauroSept® administration.
Serum tryptase levels showed a significant increase, confirming the allergic reaction.
The event suggests a rare but serious adverse reaction to taurolidine in an infant.

Conclusions:

This case represents the first reported instance of anaphylaxis to TauroSept® in an infant globally.
Healthcare providers should maintain awareness of this potential, albeit rare, side effect when using taurolidine lock solutions in pediatric patients.