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TauroSept-Induced Anaphylaxis: A Pediatric Case Report

Elise Mank1, Nancy Broos2, Ingrid Terreehorst3

  • 1Department of Pediatrics, Emma Children's Hospital, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands.

Pediatric Allergy, Immunology, and Pulmonology
|September 11, 2025
PubMed

Insights

TauroSept®, a taurolidine lock solution, is generally safe for children receiving parenteral nutrition. However, this case highlights a rare instance of anaphylaxis in an infant, emphasizing the need for clinical awareness of potential side effects.

Area of Science:

  • Pediatric Gastroenterology
  • Clinical Pharmacology

Background:

  • Children with intestinal failure require parenteral nutrition via central venous catheters, increasing their risk of catheter-related bloodstream infections.
  • Taurolidine lock solutions have been widely used for prophylaxis against these infections and are generally considered safe in pediatric populations.

Purpose of the Study:

  • To report the first documented case of anaphylaxis in an infant following the administration of TauroSept® (taurolidine).

Main Methods:

  • A case report detailing a 1-month-old infant with jejunal atresia receiving parenteral nutrition.
  • Observation of adverse events, including circulatory insufficiency and angioedema, shortly after TauroSept® administration.
  • Measurement of serum tryptase levels to assess for anaphylaxis.

Main Results:

  • The infant developed severe symptoms consistent with anaphylaxis after TauroSept® administration.
  • Serum tryptase levels showed a significant increase, confirming the allergic reaction.
  • The event suggests a rare but serious adverse reaction to taurolidine in an infant.

Conclusions:

  • This case represents the first reported instance of anaphylaxis to TauroSept® in an infant globally.
  • Healthcare providers should maintain awareness of this potential, albeit rare, side effect when using taurolidine lock solutions in pediatric patients.

Keywords:
TauroSeptallergic reactionanaphylaxischildrenpovidonetaurolidine

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