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Related Concept Videos

Overview of Exosomes01:36

Overview of Exosomes

Exosomes are stable, lipid bilayer-enclosed vesicles capable of crossing biological barriers. They can carry a wide range of molecules required for intercellular communication. Once exosomes are released from the cell where they originated, they enter a recipient cell through various pathways such as fusion, receptor-mediated endocytosis, macropinocytosis, and phagocytosis.
Stahl et al. discovered exosomes in 1983, but the exosomes were initially considered waste products released from the...
Nuclear Export of mRNA02:31

Nuclear Export of mRNA

Before mRNAs are exported to the cytoplasm, it is crucial to check each mRNA for structural and functional integrity. Eukaryotic cells use several different mechanisms, collectively known as mRNA surveillance, to look for irregularities in mRNAs. Irregular or aberrant mRNA are rapidly degraded by various enzymes. If a defective mRNA escapes the surveillance, it would be translated into a protein which would either be non-functional or not function properly. One of the primary irregularities in...

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Related Experiment Video

Updated: May 20, 2026

Preparation of Exosomes for siRNA Delivery to Cancer Cells
09:59

Preparation of Exosomes for siRNA Delivery to Cancer Cells

Published on: December 5, 2018

Exosomes as nucleic acid nanocarriers.

Jasper G van den Boorn1, Juliane Dassler, Christoph Coch

  • 1Institute for Clinical Chemistry and Clinical Pharmacology, University Hospital Bonn, Bonn, Germany. jvdboorn@uni-bonn.de

Advanced Drug Delivery Reviews
|July 4, 2012
PubMed
Summary
This summary is machine-generated.

Exosomes, natural nano-sized vesicles, are ideal for targeted in vivo delivery of nucleic acids like miRNA. Their specific loading and cell-targeting capabilities make them promising nanocarriers for therapeutic applications.

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Isolation and Characterization of RNA-Containing Exosomes
09:43

Isolation and Characterization of RNA-Containing Exosomes

Published on: January 9, 2012

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Last Updated: May 20, 2026

Preparation of Exosomes for siRNA Delivery to Cancer Cells
09:59

Preparation of Exosomes for siRNA Delivery to Cancer Cells

Published on: December 5, 2018

Isolation and Characterization of RNA-Containing Exosomes
09:43

Isolation and Characterization of RNA-Containing Exosomes

Published on: January 9, 2012

Area of Science:

  • Cell biology
  • Nanotechnology
  • Molecular biology

Background:

  • Exosomes are naturally occurring nano-sized vesicles secreted by various cell types.
  • These vesicles are endogenously loaded with specific nucleic acid cargo, including miRNA.
  • Exosomes function as intercellular communication mediators, influencing recipient cell functions.

Purpose of the Study:

  • To review current research on exosomes as nanocarriers.
  • To illustrate the potential of exosomes for targeted in vivo nucleic acid delivery.

Main Methods:

  • Literature review of existing scientific research on exosomes and nucleic acid delivery.

Main Results:

  • Exosomes possess inherent properties making them suitable for nanocarrier applications.
  • Their specific nucleic acid cargo reflects the state of the producing cell.
  • Surface tetraspanins enable selective targeting of recipient cells and tissues.

Conclusions:

  • Exosomes represent a promising platform for the targeted in vivo delivery of nucleic acids.
  • Their natural origin and targeting capabilities offer advantages over synthetic nanocarriers.