Related Experiment Video
Updated: May 20, 2026
02:28
Measuring Psoriasis Severity at Home
Published on: March 1, 2024
Pathogenetic overview of psoriatic disease
Muhammad Haroon1, Oliver Fitzgerald
1St Vincent's University Hospital and Conway Institute, University College Dublin, Dublin, Ireland.
The Journal of Rheumatology. Supplement
|July 4, 2012
Summary
Psoriatic arthritis (PsA) is a distinct inflammatory disease with autoimmune and autoinflammatory aspects. Its unique clinical, genetic, and imaging features differentiate it from other rheumatic conditions.
Area of Science:
- Rheumatology and immunology
- Musculoskeletal diseases
Background:
- Psoriatic arthritis (PsA) is an inflammatory musculoskeletal condition.
- It presents with both autoimmune and autoinflammatory characteristics.
- PsA exhibits distinct clinical, genetic, immunohistochemical, and imaging features differentiating it from other rheumatic diseases.
Purpose of the Study:
- To highlight the distinct nature of psoriatic arthritis.
- To differentiate PsA from other common rheumatic diseases based on its unique features.
- To discuss the evolving understanding of PsA pathogenesis and genetic heterogeneity.
Main Methods:
- Review of clinical, genetic, immunohistochemical, and imaging data in PsA.
- Comparison of PsA features with other rheumatic diseases.
- Analysis of newer imaging techniques for characterizing tissue abnormalities.
Main Results:
- PsA involves peripheral joints, enthesitis, distal interphalangeal joints, and axial structures.
- Evidence supports both autoimmune and autoinflammatory models for PsA pathogenesis.
- Genetic studies reveal heterogeneity in PsA, with new insights from HLA region and GWAS.
- Advanced imaging highlights distinct new bone formation in PsA compared to rheumatoid arthritis.
Conclusions:
- PsA is a unique entity with specific musculoskeletal manifestations.
- Understanding its distinct features is crucial for accurate diagnosis and management.
- Ongoing research continues to refine the understanding of PsA's complex pathogenesis and genetic landscape.
Related Concept Videos
01:24Parkinson Disease ll: Pathophysiology
Parkinson disease (PD) is a progressive neurodegenerative disorder primarily affecting movement, with additional non-motor features. Its pathophysiology involves complex interactions among genetic susceptibility, environmental exposures, and cellular dysfunction, including dopaminergic neuron loss, protein aggregation, and mitochondrial impairment.Selective NeurodegenerationA key feature is the degeneration of dopaminergic neurons in the substantia nigra pars compacta, leading to reduced...
01:27Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders
Schizophrenia is a neurodevelopmental disorder whose origins are rooted in complex genetic components. Despite our burgeoning understanding, the pathophysiology of this disorder remains incompletely deciphered.
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within the...
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within the...
01:24T Cell Types and Functions
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
01:15Parkinson's Disease: Overview
Neurodegenerative disorders are progressive diseases that cause irreversible damage and loss to neurons in specific brain areas. Examples of these disorders include Parkinson's disease, Alzheimer's disease, Multiple Sclerosis (MS), and Amyotrophic Lateral Sclerosis (ALS). These disorders share characteristics such as proteinopathies, selective neuronal vulnerability, and a complex interplay between genetic and environmental factors. The primary therapeutic goal for these conditions is to...
01:30Peripheral Artery Disease I: Introduction
Peripheral artery disease (PAD) predominantly results from atherosclerosis, which involves the accumulation of fatty deposits, or plaques, within the walls of arteries. This causes them to narrow and harden, significantly reducing blood flow. PAD predominantly affects the legs, particularly the arteries supplying the thighs and calves. In rare cases, it may involve other arteries, including those in the arms.Etiology of PAD:The principal cause of PAD is atherosclerosis, which results from fatty...
01:21Chronic Pancreatitis II: Pathophysiology
Chronic pancreatitis is a progressive and irreversible inflammation of the pancreas, most often caused by long-term alcohol abuse, but it can also be related to ductal obstruction, smoking, or genetic factors.Chronic pancreatitis occurs when the pancreas is repeatedly exposed to harmful agents like alcohol, smoking, ductal obstruction, or genetic predisposition. These factors lead to the release of toxic metabolites and inflammatory cytokines, sustaining chronic inflammation in the pancreatic...