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Related Concept Videos

Pleural Disorders: Types and Brief Description01:30

Pleural Disorders: Types and Brief Description

The pleura is a vital part of the respiratory system. It's a double-layered membrane surrounding the lungs and lining the chest cavity. The two layers of the pleura are:
Pleural Effusion II: Symptoms and Management01:28

Pleural Effusion II: Symptoms and Management

Pleural Effusion Overview
A pleural effusion is the abnormal collection of fluid between the parietal and visceral pleura layers of tissue that form the lining of the lungs and chest cavity. It can occur independently or due to surrounding parenchymal diseases, such as infection, malignancy, or inflammatory conditions.
Clinical Manifestations:
Pleural Effusion I: Introduction01:25

Pleural Effusion I: Introduction

Pleural effusion is an abnormal fluid accumulation in the pleural cavity, a narrow space between the lungs and the chest wall. It is not a disease per se but rather a symptom or indication of an underlying disease. In normal circumstances, this space contains a small amount of fluid (5 to 15 mL), a lubricant facilitating the non-frictional movement of the pleural surfaces.
There are two main types of pleural effusion: transudative and exudative. They are differentiated using Light's criteria,...
Pleura of the Lungs01:13

Pleura of the Lungs

The lungs are nestled in a cavity, shielded by the pleura. The pleura, a form of serous membrane, wraps around each lung. This membrane arrangement consists of two layers: the visceral and parietal pleurae. The visceral pleura lines the surface of the lungIn contrast, the parietal pleura is the outer layer and contacts to the thoracic wall, the mediastinum, and the diaphragm. The hilum is the point of connection between the visceral and parietal layers. The space between the parietal and...
Pneumothorax II: Pathophysiology01:08

Pneumothorax II: Pathophysiology

Pneumothorax means the presence of air in the pleural space — the thin potential gap between the visceral and parietal pleura. This condition disrupts the normal pressure balance that keeps the lungs inflated, leading to partial or complete collapse of the affected lung.Normal physiologyUnder normal conditions, the pleural space maintains a slightly negative intrapleural pressure, which keeps the lungs expanded against the chest wall. This negative pressure creates a delicate balance between...
Pulmonary Tuberculosis III01:31

Pulmonary Tuberculosis III

Tuberculosis (TB) is a contagious infection primarily affecting the lung parenchyma but which can also affect other body parts. TB can be classified based on disease development, presentation, and the affected anatomical site.
The first classification is based on the development of the disease, and it includes the following categories:

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Related Experiment Video

Updated: May 20, 2026

Implantation and Monitoring by PET/CT of an Orthotopic Model of Human Pleural Mesothelioma in Athymic Mice
07:54

Implantation and Monitoring by PET/CT of an Orthotopic Model of Human Pleural Mesothelioma in Athymic Mice

Published on: December 21, 2019

[Malignant pleural mesothelioma].

I Opitz1, W Weder

  • 1Klinik für Thoraxchirurgie, UniversitätsSpital Zürich. isabelle.schmitt-opitz@usz.ch

Therapeutische Umschau. Revue Therapeutique
|July 4, 2012
PubMed
Summary
This summary is machine-generated.

Malignant pleural mesothelioma remains a significant clinical challenge with poor prognoses. Multimodality treatment, including surgery, offers the best survival outcomes, necessitating improved staging and innovative clinical trial designs for rare cancers.

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Orthotopic Implantation and Peripheral Immune Cell Monitoring in the II-45 Syngeneic Rat Mesothelioma Model

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Generation and Expansion of Primary, Malignant Pleural Mesothelioma Tumor Lines

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Orthotopic Implantation and Peripheral Immune Cell Monitoring in the II-45 Syngeneic Rat Mesothelioma Model

Published on: October 2, 2015

Area of Science:

  • Oncology
  • Thoracic Surgery
  • Medical Research

Context:

  • Malignant pleural mesothelioma (MPM) incidence is rising globally.
  • MPM presents a significant clinical and therapeutic challenge.
  • Current treatment strategies, particularly surgery and radiotherapy, remain controversial.

Purpose:

  • To review current treatment modalities for malignant pleural mesothelioma.
  • To highlight the importance of multimodality treatment and improved staging.
  • To discuss challenges and future directions in MPM research and clinical trials.

Summary:

  • Multimodality treatment, incorporating surgery for select patients, yields the best survival data for MPM.
  • Improved staging systems and translational studies for therapy response markers are crucial.
  • Despite advances in understanding MPM biology, new treatment approvals are limited due to the rarity of the disease.

Impact:

  • Emphasizes the need for enhanced staging accuracy in MPM.
  • Suggests innovative clinical trial designs, like multi-arm multi-stage trials, to overcome patient number limitations.
  • Highlights the ongoing challenge of developing and approving new therapies for rare thoracic malignancies.