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Related Concept Videos

Multiple Sclerosis l: Introduction01:19

Multiple Sclerosis l: Introduction

Multiple sclerosis is a chronic autoimmune disease of the central nervous system (CNS) that affects the brain, spinal cord, and optic nerves. It is an inflammatory demyelinating disorder and a leading cause of neurological disability in young adults.EpidemiologyMS commonly begins between 20 and 40 years of age and is twice as common in women. Its exact cause remains unclear, but genetic susceptibility contributes, with higher risk in first-degree relatives and identical twins. A greater...
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The nursing management of Mitral Valve Prolapse, or MVP, centers around patient education, symptom monitoring, and lifestyle modifications.Patient Education on MVP Diagnosis and Heredity: Nurses should provide comprehensive education about MVP, a condition where the mitral valve does not close appropriately during heartbeats. This education often includes the condition's pathophysiology, symptoms, and potential complications, like arrhythmias or mitral regurgitation. Though not fully...
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Teratogenicity

The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...

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Related Experiment Video

Updated: May 20, 2026

Modeling Multiple Sclerosis in the Two Sexes: MOG35-55-Induced Experimental Autoimmune Encephalomyelitis
05:44

Modeling Multiple Sclerosis in the Two Sexes: MOG35-55-Induced Experimental Autoimmune Encephalomyelitis

Published on: October 13, 2023

Multiple sclerosis and pregnancy: maternal considerations.

Sura Alwan1, A Dessa Sadovnick

  • 1Department of Medical Genetics, University of British Columbia, and Vancouver Coastal Health Authority-UBC Hospital, Vancouver, BC, Canada. sura.alwan@gmail.com

Women'S Health (London, England)
|July 5, 2012
PubMed
Summary
This summary is machine-generated.

Pregnancy in women with multiple sclerosis (MS) does not harm long-term disease progression and may even reduce relapses, particularly during the third trimester. Postpartum relapses may increase, but overall, pregnancy is manageable for MS patients.

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Last Updated: May 20, 2026

Modeling Multiple Sclerosis in the Two Sexes: MOG35-55-Induced Experimental Autoimmune Encephalomyelitis
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Using a Murine Model of Psychosocial Stress in Pregnancy as a Translationally Relevant Paradigm for Psychiatric Disorders in Mothers and Infants
06:39

Using a Murine Model of Psychosocial Stress in Pregnancy as a Translationally Relevant Paradigm for Psychiatric Disorders in Mothers and Infants

Published on: June 13, 2021

Area of Science:

  • Neurology
  • Reproductive Medicine
  • Immunology

Background:

  • Multiple sclerosis (MS) is a leading neurological disorder in young adults.
  • A significant female predominance exists (3:1 ratio).
  • Pregnancy in MS patients raises numerous clinical questions.

Purpose of the Study:

  • To evaluate the impact of pregnancy on the long-term progression of multiple sclerosis.
  • To assess the safety of pregnancy for both the mother and the fetus in the context of MS.
  • To review current understanding of disease-modifying therapies during pregnancy.

Main Methods:

  • Literature review of studies examining pregnancy outcomes in women with MS.
  • Analysis of relapse rates before, during, and after pregnancy.
  • Assessment of fertility, congenital anomaly, and complication risks.

Main Results:

  • Pregnancy does not negatively affect the long-term course of MS.
  • A protective effect against relapses is observed, especially in the third trimester.
  • Postpartum relapse rates may increase in the initial months.
  • MS does not significantly impact fertility or increase risks of congenital anomalies or pregnancy complications.
  • Beta-interferon use during conception/pregnancy has potential adverse reproductive outcomes, with FDA warnings issued.

Conclusions:

  • Pregnancy is generally safe for women with multiple sclerosis and may offer a protective effect on disease activity.
  • Careful consideration of disease-modifying therapies, such as beta-interferons, is crucial during conception and pregnancy due to potential risks.