Related Experiment Video
Updated: May 20, 2026

10:22
High Speed Droplet-based Delivery System for Passive Pumping in Microfluidic Devices
Published on: September 2, 2009
An electrokinetically driven micro liquid piston for leak-tight gas pumping.
1Department of Electrical and Computer Engineering, University of Missouri, Columbia, MO, USA.
Lab on a Chip
|July 5, 2012
Summary
This study introduces a novel electrokinetic liquid piston for microfluidic gas pumping. This technique achieves complete sealing and leak-tight operation with zero dead volume, enabling effective gas manipulation.
Area of Science:
- Microfluidics
- Fluid Dynamics
- Electrokinetics
Background:
- Microfluidic devices require precise control over fluid and gas movement.
- Traditional gas pumping methods in microfluidics can suffer from leakage and dead volume issues.
- Developing efficient and leak-tight gas handling is crucial for microfluidic applications.
Purpose of the Study:
- To present a novel gas pumping technique using an electrokinetically driven liquid piston.
- To demonstrate the capability of this liquid piston for complete sealing in microfluidic channels.
- To achieve effective gas manipulation with zero dead volume and no backflow.
Main Methods:
- Development of an electrokinetically driven liquid piston.
- Integration of the liquid piston into a microfluidic channel.
- Demonstration of the liquid piston's sealing and pumping capabilities for gaseous media.
Main Results:
- The liquid piston provided complete sealing by fully wetting the microfluidic channel's inner surface.
- Effective pushing and pulling of gaseous media were achieved.
- Leak-tight gas pumping with zero dead volume was successfully demonstrated.
Conclusions:
- The electrokinetically driven liquid piston is a viable technique for microfluidic gas pumping.
- This method overcomes limitations of dead volume and backflow in microfluidic gas handling.
- The demonstrated technique offers a promising solution for precise gas control in microfluidic systems.
Related Concept Videos
The Joule and Joule–Thomson Experiments
Consider an adiabatic system composed of two chambers, A and B, designed such that no heat flows into or out of the system. Initially, chamber A is filled with a gas at a fixed temperature T1, pressure p1, and volume V1, while chamber B is evacuated. The gas is then gradually forced through a rigid, porous barrier to chamber B, ultimately reaching temperature T2, pressure p2, and volume V2. A piston on the right side maintains a constant pressure (p2), which is lower than p1. The significant...
Application of Pascal's Law
Pascal's experimentally proven observations—that a change in pressure applied to an enclosed fluid is transmitted undiminished throughout the fluid and to the walls of its container—provide the foundations for hydraulics, one of the most important developments in modern mechanical technology.
Hydraulic systems are used to operate automotive brakes, hydraulic jacks, and numerous other mechanical systems. We can derive a relationship between the forces in a simple hydraulic system by applying...
Hydraulic systems are used to operate automotive brakes, hydraulic jacks, and numerous other mechanical systems. We can derive a relationship between the forces in a simple hydraulic system by applying...
High-Performance Liquid Chromatography: Elution Process
In High-Performance Liquid Chromatography (HPLC), the elution process is critical to the separation of analytes and the quality of chromatographic results. Elution describes how compounds move through the column and separate based on their interactions with the mobile and stationary phases. This process determines the resolution, peak shape, and retention times in the chromatogram, which are essential for identifying and quantifying components in complex mixtures. Understanding the elution...

