Related Experiment Video
Updated: May 20, 2026
11:13
Creating Sub-50 Nm Nanofluidic Junctions in PDMS Microfluidic Chip via Self-Assembly Process of Colloidal Particles
Published on: March 13, 2016
Control of DNA capture by nanofluidic transistors
Kee-Hyun Paik1, Yang Liu, Vincent Tabard-Cossa
1Department of Electrical Engineering, Stanford University, Stanford, California 94305, USA.
ACS Nano
|July 6, 2012
Summary
Researchers developed nanofluidic transistors using solid-state pores to control DNA movement. These devices achieve significant, reversible changes in DNA capture rates with low voltage, paving the way for advanced biosensing applications.
Area of Science:
- Nanotechnology
- Biophysics
- Materials Science
Background:
- Solid-state nanopores are crucial for single-molecule analysis.
- Controlling molecular transport through nanopores remains a challenge.
Purpose of the Study:
- To engineer electronically tunable nanofluidic transistors for DNA manipulation.
- To investigate the mechanisms behind controlled DNA capture and passage.
Main Methods:
- Fabrication of electrically gated solid-state pores (~200 nm).
- Utilizing sub-1 V gate electrode biasing to control DNA transport.
- Employing quantitative numerical simulations to analyze fluid dynamics.
Main Results:
- Achieved reversible alteration of DNA capture rates exceeding 3 orders of magnitude.
- Demonstrated efficient gating through the counter-balance of electrophoresis and electroosmosis.
- Validated the functionality of nanofluidic transistors for biomolecular manipulation.
Conclusions:
- Developed a novel electronically tunable biomolecular switch for nucleic acid delivery.
- Established a foundational step towards active control of DNA motion in solid-state nanopores for sensing.
- Highlighted the potential of nanofluidic transistors in advanced biosensing and fluidic circuits.
