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Nanomembrane-based microfluidic platform with embedded electrical pressure transducer for on-chip nanoparticle

Zachary Morris1,2, Juliana Chawich1, Owen Perreault1

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This study presents a novel microfluidic device for nanoparticle quantification. It uses a silicon nitride membrane and pressure transducer for accurate, non-optical measurement of particle concentrations up to 10^8 particles/mL.

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Area of Science:

  • Nanotechnology
  • Microfluidics
  • Materials Science

Background:

  • Accurate nanoparticle quantification is crucial for nanomedicine, electronics, and catalysis.
  • Existing microfluidic quantification methods face challenges with small sample volumes and optical interference.

Purpose of the Study:

  • To develop a low-cost, non-optical microfluidic device for precise nanoparticle concentration measurement.
  • To integrate an ultrathin silicon nitride nanoporous membrane with an on-chip pressure transducer.

Main Methods:

  • Utilized pressure-driven flow to capture nanoparticles on a nanoporous membrane.
  • Employed an on-chip pressure transducer measuring changes in ionic flow resistance due to membrane deflection.
  • Developed a statistical model for nanoporous membrane blockage and particle caking.

Main Results:

  • Demonstrated nanoparticle concentration determination via analysis of trans-membrane pressure change kinetics.
  • Achieved a lower limit of detection on the order of 10^8 particles per mL.
  • Validated the statistical model with experimental data from the microfluidic device.

Conclusions:

  • The developed microfluidic device offers a versatile, non-optical approach for in situ nanoparticle quantification.
  • The integrated system overcomes limitations of previous microfluidic quantification techniques.
  • The statistical model enhances understanding of nanoparticle filtration and enables accurate concentration determination.