Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Skin Diseases and Disorders

Skin Diseases and Disorders

Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...

Staphylococcal Skin Infections

Staphylococcal Skin Infections

Staphylococcus aureus is a Gram-positive coccus that resides harmlessly on the skin and mucous membranes of healthy individuals. When the skin barrier is breached, it can shift from a commensal to an opportunistic pathogen. This transition is facilitated by surface adhesins, such as clumping factor B and S. aureus surface protein G (SasG), which bind to structural proteins, including loricrin and cytokeratin, in the damaged epidermis. Protein A, another key factor, binds the Fc region of...

Hypersensitivity Reactions: Immune-Complex Reactions

Hypersensitivity Reactions: Immune-Complex Reactions

Type III hypersensitivity reactions occur when antigen–antibody complexes form and activate the complement system. Normally, these complexes help the clearance of antigens by phagocytes and red blood cells. However, when large numbers of immune complexes are present, they can deposit in tissues—particularly in the walls of blood vessels—leading to inflammation and tissue injury. These deposits trigger complement activation and neutrophil recruitment, resulting in serum sickness, a systemic...

Skin Cancer

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...

Acne Infection

Acne Infection

Acne is a multifactorial skin condition primarily affecting adolescents and young adults, with a global prevalence estimated to exceed 75% in this demographic. The condition is characterized by the formation of comedones (blackheads and whiteheads), papules, pustules, nodules, and, in severe cases, cysts, particularly in areas rich in sebaceous glands such as the face, neck, chest, and back. The pathogenesis involves increased sebum production, follicular hyperkeratinization, colonization by...

Endocarditis II: Clinical Features of Infective Endocarditis

Endocarditis II: Clinical Features of Infective Endocarditis

Endocarditis can present various clinical features depending on the causative organism and the patient's underlying health conditions. Initially, the clinical features of infective endocarditis develop gradually, presenting with nonspecific symptoms that can be easily mistaken for other illnesses.General SymptomsEarly symptoms of infective endocarditis are fever, chills, weakness, malaise, fatigue, and weight loss. These symptoms reflect the systemic nature of the infection and the body's...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Metastatic Primary Extramammary Paget Disease: A Case Series.

Cutis·2026

Same author

Rapid remission of Hailey-Hailey disease with tirzepatide therapy: A case report.

JAAD case reports·2026

Same author

Pigmentary Disorders in Skin of Color: Histopathologic Overview.

Dermatologic clinics·2026

Same author

Management of Multiple Miliary Osteoma Cutis Using CO<sub>2</sub> Laser: A Case-Based Exploration.

The Journal of clinical and aesthetic dermatology·2026

Same author

Diameter, height, and volume as macroscopic predictors of photocarcinogenesis in UV-induced SKH1 papules.

Journal of photochemistry and photobiology. B, Biology·2026

Same author

Letter to the editor - "Re: Tinea labialis in a patient with Schnitzler syndrome on interleukin-1 receptor antagonist".

JAAD case reports·2026

Search research articles

Related Experiment Video

Updated: May 20, 2026

Granulocyte-dependent Autoantibody-induced Skin Blistering

Granulocyte-dependent Autoantibody-induced Skin Blistering

Published on: October 12, 2012

Bullous dermatitis artefacta.

Olayemi Sokumbi¹, Nneka I Comfere, Marian T McEvoy

¹Department of Dermatology, Mayo Clinic, Rochester, MN 55905, USA.

The American Journal of Dermatopathology

|July 10, 2012

Summary

This summary is machine-generated.

Bullous artefactual dermatoses, often caused by heat or electrical injury, present unique diagnostic challenges. Histopathology is crucial for identifying these factitial injuries and distinguishing them from autoimmune blistering diseases.

More Related Videos

Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis

Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis

Published on: December 15, 2011

Related Experiment Videos

Last Updated: May 20, 2026

Granulocyte-dependent Autoantibody-induced Skin Blistering

Granulocyte-dependent Autoantibody-induced Skin Blistering

Published on: October 12, 2012

Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis

Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis

Published on: December 15, 2011

Area of Science:

Dermatology
Pathology

Background:

Bullous artefactual dermatoses are rare skin conditions that can be induced by physical or chemical agents.
Diagnosing factitial etiology and the specific mechanism of injury can be challenging.

Observation:

This study details two patients with bullous disease resulting from electrical current or heat exposure.
Clinical presentation included geometrically shaped tense bullae.
Histopathology revealed epidermal necrosis, subepidermal clefting, and dermal collagen homogenization.

Findings:

One patient exhibited characteristic vertical elongation of keratinocyte nuclei, indicative of electrical or thermal injury.
Immunofluorescence studies ruled out autoimmune blistering diseases like bullous pemphigoid.

Implications:

Histopathological examination is essential for diagnosing bullous dermatitis artefacta.
Findings underscore the importance of considering iatrogenic or self-inflicted causes in blistering skin conditions.