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Updated: May 20, 2026
05:19
Surgical Models of Gastroesophageal Reflux with Mice
Published on: August 25, 2015
Reflux and aerodigestive tract diseases
Andrés Coca-Pelaz1, Juan P Rodrigo, Daniela Paccagnella
1Department of Otolaryngology, Hospital Universitario Central de Asturias, Oviedo, Spain.
Summary
Laryngopharyngeal reflux (LPR) often presents without typical heartburn, making diagnosis challenging. Treatment response with proton pump inhibitors frequently confirms LPR, even with non-acidic reflux.
Area of Science:
- Gastroenterology
- Otolaryngology
Background:
- Gastroesophageal reflux disease (GERD) can manifest with diverse extraesophageal symptoms.
- Laryngopharyngeal reflux (LPR) is particularly difficult to diagnose due to the lack of classic GERD symptoms like heartburn or regurgitation.
Purpose of the Study:
- To review current knowledge on laryngopharyngeal reflux (LPR) manifestations.
- To clarify the relationship between refluxed gastric content and related diseases.
- To elucidate the pathophysiology, symptoms, and treatment of LPR.
Main Methods:
- Literature review of extraesophageal symptoms related to GERD.
- Analysis of diagnostic challenges in LPR.
- Evaluation of treatment responses, including proton pump inhibitors (PPIs), as a diagnostic tool.
Main Results:
- Diagnostic tools for reflux are often insufficient, leading to diagnosis by exclusion.
- Proton pump inhibitor (PPI) treatment can alleviate symptoms and respiratory complications, often serving to confirm the diagnosis.
- Non-acidic reflux may persist despite successful symptom management.
Conclusions:
- LPR presents diagnostic challenges due to atypical symptoms.
- Therapeutic trials with PPIs are crucial for confirming LPR and managing its diverse manifestations.
- Understanding the pathophysiology and varied presentations of LPR is essential for effective patient care.
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