Related Experiment Video
Updated: May 20, 2026

Culturing Primary Rat Inner Medullary Collecting Duct Cells
Published on: June 21, 2013
[Research advances on aquaporins and vascular function regulation and related diseases]
Shao-Qiang Liu1, Lu Tie, Xue-Jun Li
1Department of Pharmacology, School of Basic Medical Sciences, Peking University, Beijing 100191, China.
Abstract:
Aquaporins (AQPs), mainly distributed in epithelial and endothelial cells, are a family of channel-forming membrane proteins, originally confirmed to mediate the cellular water-transportation. AQPs are essential for maintaining homeostasis of the body water. Recently, studies have shown that AQPs may be involved in vascular function regulation and the development of related diseases, especially in cerebral ischemia, congestion heart failure, hypertension and tumor angiogenesis. Therefore, further studies are needed to elucidate mechanism accounting for the association between AQPs and vascular function related diseases, which may lead to novel approaches to the prevention and treatment of these diseases. In this review, we will discuss the expression and physiological roles of AQPs in vascular tissues and summarize recent progress in the relationship between AQPs and vascular function related diseases.
More Related Videos
Related Concept Videos
Aquaporins
Regulation of Water Intake
Diabetes Insipidus II: Pathophysiology
Regulation of Water Output
Physiology of the Genitourinary System III: Urine Concentration and Dilution
Overview of the Vascular System

