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Related Concept Videos

Translation01:31

Translation

Lesson: Translation
Translation is the process of synthesizing proteins from the genetic information carried by messenger RNA (mRNA). Following transcription, it constitutes the final step in the expression of genes. This process is carried out by ribosomes, complexes of protein and specialized RNA molecules. Ribosomes, transfer RNA (tRNA), and other proteins produce a chain of amino acids—the polypeptide—as the end product of translation.
Translation Produces the Building Blocks of Life
Translation01:31

Translation

Lesson: Translation
Translation is the process of synthesizing proteins from the genetic information carried by messenger RNA (mRNA). Following transcription, it constitutes the final step in the expression of genes. This process is carried out by ribosomes, complexes of protein and specialized RNA molecules. Ribosomes, transfer RNA (tRNA), and other proteins produce a chain of amino acids—the polypeptide—as the end product of translation.
Translation Produces the Building Blocks of Life
Improving Translational Accuracy02:07

Improving Translational Accuracy

Base complementarity between the three base pairs of mRNA codon and the tRNA anticodon is not a failsafe mechanism. Inaccuracies can range from a single mismatch to no correct base pairing at all. The free energy difference between the correct and nearly correct base pairs can be as small as 3 kcal/ mol. With complementarity being the only proofreading step, the estimated error frequency would be one wrong amino acid in every 100 amino acids incorporated. However, error frequencies observed in...
Improving Translational Accuracy02:07

Improving Translational Accuracy

Base complementarity between the three base pairs of mRNA codon and the tRNA anticodon is not a failsafe mechanism. Inaccuracies can range from a single mismatch to no correct base pairing at all. The free energy difference between the correct and nearly correct base pairs can be as small as 3 kcal/ mol. With complementarity being the only proofreading step, the estimated error frequency would be one wrong amino acid in every 100 amino acids incorporated. However, error frequencies observed in...
Transfer RNA Synthesis02:36

Transfer RNA Synthesis

One of the unique features of tRNA is the presence of modified bases. In some tRNAs, modified bases account for nearly 20% of the total bases in the molecule. Altogether, these unusual bases protect the tRNA from enzymatic degradation by RNases.
Each of these chemical modifications is carried by a specific enzyme, post-transcription. All of these enzymes have unique base and site-specificity. Methylation, the most common chemical modification, is carried by at least nine different enzymes, with...
Synthetic Biology02:55

Synthetic Biology

Synthetic biology is an interdisciplinary science that involves using principles from disciplines such as engineering, molecular biology, cell biology, and systems biology. It involves remodeling existing organisms from nature or constructing completely new synthetic organisms for applications such as protein or enzyme production, bioremediation, value-added macromolecule production, and the addition of desirable traits to crops, to name a few.
Golden rice
Golden rice is a genetically modified...

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Related Experiment Video

Updated: May 20, 2026

Evidence-based Knowledge Synthesis and Hypothesis Validation: Navigating Biomedical Knowledge Bases via Explainable AI and Agentic Systems
05:47

Evidence-based Knowledge Synthesis and Hypothesis Validation: Navigating Biomedical Knowledge Bases via Explainable AI and Agentic Systems

Published on: June 13, 2025

Moving knowledge into action: developing the rapid synthesis and translation process within the interactive systems

Sally Thigpen1, Richard W Puddy, Helen Harber Singer

  • 1Centers for Disease Control and Prevention, Atlanta, GA, USA. sti9@cdc.gov

American Journal of Community Psychology
|July 11, 2012
PubMed
Summary
This summary is machine-generated.

The Rapid Synthesis and Translation Process (RSTP) expedites research dissemination for violence prevention. This six-step method, developed by the CDC, translates knowledge into action for practitioners.

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The Participant-Reported Implementation Update and Score (PRIUS): A Novel Method for Capturing Implementation-Related Data Over Time
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The Participant-Reported Implementation Update and Score (PRIUS): A Novel Method for Capturing Implementation-Related Data Over Time

Published on: February 19, 2021

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Last Updated: May 20, 2026

Evidence-based Knowledge Synthesis and Hypothesis Validation: Navigating Biomedical Knowledge Bases via Explainable AI and Agentic Systems
05:47

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Published on: June 13, 2025

The Participant-Reported Implementation Update and Score (PRIUS): A Novel Method for Capturing Implementation-Related Data Over Time
06:05

The Participant-Reported Implementation Update and Score (PRIUS): A Novel Method for Capturing Implementation-Related Data Over Time

Published on: February 19, 2021

Area of Science:

  • Dissemination and Implementation Science
  • Public Health
  • Knowledge Translation

Background:

  • The Interactive Systems Framework (ISF) provides a structure for translating research into practice.
  • Specific ISF systems require further development for practical application.
  • Effective knowledge transfer is crucial for evidence-based interventions.

Purpose of the Study:

  • To describe the development and application of the Rapid Synthesis and Translation Process (RSTP).
  • To illustrate how a federal agency can accelerate research-to-practice transfer for violence prevention.
  • To demonstrate the RSTP within the ISF's Prevention Synthesis and Translation System.

Main Methods:

  • The study outlines a six-step process for rapid knowledge synthesis and translation.
  • The exchange model of knowledge transfer guides the RSTP.
  • Practitioner and researcher feedback were integrated into the process.

Main Results:

  • The RSTP was developed and initially applied by the Division of Violence Prevention at the CDC.
  • The process facilitates the transfer of research knowledge to practitioners.
  • The RSTP impacts both prevention support and delivery.

Conclusions:

  • The RSTP is a viable method for expediting knowledge translation in public health.
  • The process can be adapted by federal agencies to improve evidence uptake.
  • Continuous feedback integration enhances the effectiveness of knowledge translation efforts.