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Updated: May 20, 2026

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Microfluidic cell volume sensor with tunable sensitivity.

Jason Riordon1, Maryam Mirzaei, Michel Godin

  • 1Physics Department, University of Ottawa, Ottawa, Ontario, Canada K1N 6N5.

Lab on a Chip
|July 12, 2012
PubMed
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We developed a new microfluidic sensor on a PDMS chip to measure cell volume. This tunable sensor can detect individual bacteria and microparticles with adjustable sensitivity.

Area of Science:

  • Biomedical Engineering
  • Microfluidics
  • Sensor Technology

Background:

  • Accurate cell volume measurement is crucial for understanding cellular processes.
  • Existing methods for cell volume sensing can be complex or lack sensitivity.
  • Microfluidic devices offer miniaturized platforms for biological analysis.

Purpose of the Study:

  • To fabricate and validate a novel microfluidic cell volume sensor.
  • To integrate a tunable detection volume for dynamic sensitivity control.
  • To demonstrate the sensor's capability for detecting individual Escherichia coli and microparticles.

Main Methods:

  • Fabrication of a multi-layered polydimethylsiloxane (PDMS) microchip.
  • Integration of a microfluidic cell volume sensor with tunable detection volume.

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Published on: December 2, 2022

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  • Validation using individual Escherichia coli and standard microparticles.

    • Main Results:

    • Successful fabrication and validation of the microfluidic sensor.
    • Demonstrated dynamic control of sensitivity via tunable detection volume.
    • Achieved reliable detection of individual Escherichia coli and microparticles.

    Conclusions:

    • The developed microfluidic sensor provides a sensitive and adaptable platform for cell volume analysis.
    • Tunable detection volume allows for optimized sensitivity in detecting various biological entities.
    • This technology has potential applications in microbiology and particle analysis.