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Updated: May 20, 2026

Investigating Drivers of Antireward in Addiction Behavior with Anatomically Specific Single-Cell Gene Expression Methods
Published on: August 4, 2022
Office-based opioid dependence treatment
James Colson1, Standiford Helm, Sanford M Silverman
1West Virginia University Hospitals, Morgantown, WV 26506, USA. colsonj@wvuhealthcare.com
Opioid antagonists and partial agonists are effective in preventing opioid tolerance and dependence. These medications are revolutionizing opioid dependence therapy, offering new office-based treatment options.
Area of Science:
- Pharmacology
- Addiction Medicine
- Public Health
Background:
- Increasing prevalence of opioid misuse and abuse in chronic non-cancer pain management.
- Development of opioid-related drugs with altered mu receptor activity.
- Opioid antagonists and partial agonists modulate tolerance and dependence.
Purpose of the Study:
- Evaluate therapeutic utility of opioid antagonists and partial agonists.
- Assess their role in preventing opioid tolerance and dependence.
- Focus on office-based practice applications.
Main Methods:
- Narrative review of current literature (2008-2010).
- Computerized database searches (PubMed, EMBASE, BioMed, Cochrane).
- Inclusion of reviews, studies, and FDA/manufacturer data.
Main Results:
- Opioid antagonists and partial agonists are used in abuse deterrent strategies.
- These agents aid in opioid detoxification and withdrawal management.
- Buprenorphine and buprenorphine/naloxone have transformed therapy.
Conclusions:
- Opioid dependency remains a significant public health issue.
- DATA 2000 and FDA-approved medications revolutionized treatment.
- Office-based buprenorphine treatment challenges traditional methadone maintenance.
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