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[Side effects of antiviral therapy in patients with chronic hepatitis C infection]

Velimir Kostić1, Maja Jovanović, Jelena Radović

  • 1Klinika za infektivne bolesti, Klinicki centar Nis prof.vel.kos@gmail.com

Medicinski Pregled
|July 14, 2012
PubMed

Insights

Pegylated-interferon and ribavirin therapy for chronic hepatitis C showed varied sustained virological response rates, with lower efficacy in dialysis patients. Adverse effects like anemia and flu-like syndrome were common, necessitating dose modifications.

Area of Science:

  • Hepatology
  • Virology
  • Pharmacology

Context:

  • Chronic hepatitis C is a significant global health concern.
  • Pegylated-interferon and ribavirin are standard therapies.
  • Comorbidities like kidney dialysis and hemophilia may impact treatment outcomes.

Purpose:

  • To evaluate the efficacy and safety of pegylated-interferon and ribavirin therapy in chronic hepatitis C patients with varying comorbidities.
  • To compare sustained virological response rates and adverse events across different patient groups.

Summary:

  • Eighty-eight chronic hepatitis C patients were divided into three groups: no comorbidity, on dialysis, and with hemophilia.
  • Dialysis patients exhibited a significantly lower sustained virological response (p < 0.05) and a higher incidence of hematological side effects (p < 0.01), including anemia and leukopenia.
  • The most frequent clinical side effect was a flu-like syndrome, observed in over half the patients.

Impact:

  • Treatment outcomes for chronic hepatitis C can be influenced by patient comorbidities, particularly kidney dialysis.
  • Adverse events, including hematological changes and flu-like symptoms, are common and may require dose adjustments.
  • Understanding these variations is crucial for optimizing hepatitis C treatment strategies.
Abstract

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