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An Efficient and Simple Method to Establish NK and T Cell Lines from Patients with Chronic Active Epstein-Barr Virus Infection
09:43

An Efficient and Simple Method to Establish NK and T Cell Lines from Patients with Chronic Active Epstein-Barr Virus Infection

Published on: March 30, 2018

[Rash in primary Epstein-Barr virus infection]

Dajana Lendak1, Dunja Mihajlović, Vesna Turkulov

  • 1Klinika za infektivne bolesti Klinicki centar Vojvodine, Novi Sad. dajanalendak@gmail.com

Medicinski Pregled
|July 14, 2012
PubMed
Abstract

Insights

Rash in acute infectious mononucleosis is not linked to clinical factors. While all antimicrobials can cause rash, third-generation cephalosporins appear less likely to do so compared to other drug classes.

Area of Science:

  • Infectious Diseases
  • Pharmacology
  • Dermatology

Context:

  • Acute infectious mononucleosis, a common viral illness, can present with a rash.
  • Previous literature suggested a link between synthetic penicillins and Epstein-Barr virus (EBV) infection-related rashes.
  • Recent reports indicate a broader range of antimicrobials may be associated with rash development in EBV infections.

Purpose:

  • To investigate the correlation between antimicrobial administration, clinical factors, and rash development in patients with acute infectious mononucleosis.
  • To re-evaluate the association between specific antibiotic classes and rash incidence in EBV infection.

Summary:

  • A study of 243 patients with acute infectious mononucleosis found no significant differences in clinical or laboratory markers between those with and without rash.
  • No significant difference in rash occurrence was observed with synthetic penicillins, macrolides, or first/second-generation cephalosporins.
  • Third-generation cephalosporins were associated with a lower frequency of rash compared to other antimicrobials, and only two patients developed rash without any antimicrobial exposure.

Impact:

  • Challenges the long-held belief that synthetic penicillins are a primary cause of rash in infectious mononucleosis.
  • Suggests that while various antimicrobials can trigger rash, third-generation cephalosporins may offer a safer profile in this regard.
  • Highlights the need for further research into the specific mechanisms of drug-induced rash in viral infections.

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