Related Experiment Video
Updated: May 20, 2026
09:43
An Efficient and Simple Method to Establish NK and T Cell Lines from Patients with Chronic Active Epstein-Barr Virus Infection
Published on: March 30, 2018
[Rash in primary Epstein-Barr virus infection]
Dajana Lendak1, Dunja Mihajlović, Vesna Turkulov
1Klinika za infektivne bolesti Klinicki centar Vojvodine, Novi Sad. dajanalendak@gmail.com
Medicinski Pregled
|July 14, 2012
Summary
Rash in acute infectious mononucleosis is not linked to clinical factors. While all antimicrobials can cause rash, third-generation cephalosporins appear less likely to do so compared to other drug classes.
Area of Science:
- Infectious Diseases
- Pharmacology
- Dermatology
Context:
- Acute infectious mononucleosis, a common viral illness, can present with a rash.
- Previous literature suggested a link between synthetic penicillins and Epstein-Barr virus (EBV) infection-related rashes.
- Recent reports indicate a broader range of antimicrobials may be associated with rash development in EBV infections.
Purpose:
- To investigate the correlation between antimicrobial administration, clinical factors, and rash development in patients with acute infectious mononucleosis.
- To re-evaluate the association between specific antibiotic classes and rash incidence in EBV infection.
Summary:
- A study of 243 patients with acute infectious mononucleosis found no significant differences in clinical or laboratory markers between those with and without rash.
- No significant difference in rash occurrence was observed with synthetic penicillins, macrolides, or first/second-generation cephalosporins.
- Third-generation cephalosporins were associated with a lower frequency of rash compared to other antimicrobials, and only two patients developed rash without any antimicrobial exposure.
Impact:
- Challenges the long-held belief that synthetic penicillins are a primary cause of rash in infectious mononucleosis.
- Suggests that while various antimicrobials can trigger rash, third-generation cephalosporins may offer a safer profile in this regard.
- Highlights the need for further research into the specific mechanisms of drug-induced rash in viral infections.
Related Concept Videos
01:19Encephalitis l: Introduction
Encephalitis is inflammation of the brain parenchyma, most often due to infections or autoimmune processes. It presents with neuropsychiatric features such as fever, altered mental status, behavioral changes, cognitive dysfunction, seizures, focal deficits, and sometimes autonomic instability. In some cases, the meninges are also involved, resulting in meningoencephalitis.Infectious CausesInfectious encephalitis is most commonly viral but can also result from bacterial, fungal, or parasitic...
01:26Encephalitis ll: Pathophysiology
Encephalitis is inflammation of the brain parenchyma caused by direct viral invasion or immune-mediated mechanisms triggered by infections or tumors. Both processes lead to neuronal injury, disrupted neurotransmission, and diverse neurological symptoms, often with overlapping clinical and pathological features.Autoimmune EncephalitisIn autoimmune encephalitis, antibodies target neuronal antigens on cell surfaces, synapses, or within neurons. A key example is anti-NMDAR encephalitis, which can...
01:23Rheumatic Heart Disease I: Introduction
Rheumatic heart disease or RHD is a chronic condition that results from rheumatic fever, causing permanent damage to the heart valves.Etiology and Risk FactorsIt primarily arises from rheumatic fever, an inflammatory disease that can develop after untreated or inadequately treated group A streptococcal (GAS) pharyngitis. Streptococcus spreads through direct contact with oral or respiratory secretions. While the bacteria are the causative agents, factors like malnutrition, overcrowding, poor...
01:27Cytomegalovirus Disease
Cytomegalovirus (CMV) disease is caused by human cytomegalovirus, a double-stranded DNA virus of the Herpesviridae family. While primary CMV infection is often asymptomatic in immunocompetent individuals, the virus can cause severe disease in neonates and immunocompromised patients. CMV is the most common cause of congenital viral infection in the United States, and a major pathogen in solid organ and hematopoietic stem cell transplant recipients.CMV is transmitted via bodily fluids, sexual...
01:28Viral Hepatitis I: Introduction
Viral hepatitis is an inflammatory condition of the liver caused by infection with hepatotropic viruses, most commonly hepatitis A, B, C, D, and E. Despite variations in structure and transmission, all viruses mentioned infect hepatocytes and provoke immune responses that can hinder liver function. Additionally, some non-hepatotropic viruses can also lead to hepatic inflammation.Hepatitis A VirusHepatitis A virus (HAV) is transmitted through the fecal–oral route, typically by ingestion of food...
01:16Primary Lymphoid Organs
Primary lymphoid organs are pivotal in the formation, development, and maturation of lymphocytes, the white blood cells that serve as the backbone of our immune system. This crucial function underscores their fundamental role in maintaining our overall health and immunity. The two primary lymphoid organs of prime importance are the red bone marrow and the thymus.
The red bone marrow is a soft, spongy tissue nestled in the interior of long bones such as the humerus and femur. It is the site...
The red bone marrow is a soft, spongy tissue nestled in the interior of long bones such as the humerus and femur. It is the site...