Related Experiment Video
Updated: May 20, 2026
09:47
Isolation, Processing and Analysis of Murine Gingival Cells
Published on: July 2, 2013
Programmed cell death and its possible relationship with periodontal disease
Hiromasa Tsuda1, Zhao Ning, Yoko Yamaguchi
1Department of Biochemistry, Nihon University School of Dentistry, Tokyo, Japan. tsuda-h@dent.nihon-u.ac.jp
Journal of Oral Science
|July 14, 2012
Summary
Programmed cell death, including apoptosis and necroptosis, plays a role in health and disease. This overview explores programmed cell death types and their link to periodontal disease initiation.
Area of Science:
- Cell Biology
- Immunology
- Periodontology
Background:
- Cell death is crucial for physiological processes and tissue homeostasis.
- Dysregulation of programmed cell death is implicated in various diseases like cancer and neurodegeneration.
- Apoptosis is a well-understood form of programmed cell death, but other types like necroptosis and autophagic cell death are increasingly recognized.
Purpose of the Study:
- To provide an overview of different programmed cell death types: apoptosis, necroptosis, and autophagic cell death.
- To discuss damage-associated molecular patterns (DAMPs) and their pro-inflammatory roles.
- To explore the potential connection between programmed cell death, DAMPs, and the initiation of periodontal disease.
Main Methods:
- Literature review and synthesis of current research on programmed cell death.
- Examination of the role of damage-associated molecular patterns (DAMPs).
- Hypothetical model development linking cell death mechanisms to periodontal disease.
Main Results:
- Identified and described apoptosis, necroptosis, and autophagic cell death as key programmed cell death pathways.
- Highlighted the pro-inflammatory nature of DAMPs released during cell death.
- Proposed a hypothetical mechanism for the involvement of programmed cell death and DAMPs in periodontal disease.
Conclusions:
- Programmed cell death is a fundamental biological process with implications for numerous diseases.
- DAMPs released from dying cells can trigger inflammatory responses.
- Programmed cell death and DAMPs may play a significant role in the initiation and progression of periodontal disease.
Related Concept Videos
01:30Overview of Cell Death
Cell death is an essential process where the body gets rid of old or damaged cells. Cell proliferation and death need to be balanced, as an imbalance between the two may lead to cancer or autoimmune diseases.
Cell death was observed in the early 19th century, but there was no experimental evidence to prove it. In 1842, Carl Vogt first discovered cell death in a metamorphic toad; however, it was not termed ‘cell death.’ Scientists discovered different cell death pathways only in the 20th century...
Cell death was observed in the early 19th century, but there was no experimental evidence to prove it. In 1842, Carl Vogt first discovered cell death in a metamorphic toad; however, it was not termed ‘cell death.’ Scientists discovered different cell death pathways only in the 20th century...
01:22Cellular Injury V: Apoptosis and Autophagy
Cells respond to damage and stress through highly coordinated processes that decide whether they survive or undergo controlled self-destruction. Two major pathways involved in this regulation are apoptosis, a type of programmed cell death, and autophagy, a survival mechanism that helps cells adapt to adverse conditions.ApoptosisApoptosis removes aged or injured cells to maintain tissue balance. During this process, the cell shrinks, chromatin condenses and fragments, and membrane-bound...
01:30Apoptosis
Apoptosis is a combination of two Greek words, 'apo' and 'ptosis,' meaning separation and falling off, respectively. Hippocrates used this word to describe gangrene, which was caused due to bandaging of fractured bones. Apoptosis was distinguished from necrosis in 1970 when John Kerr reported observations of morphological changes occurring during apoptosis. During one experiment, he observed that the disruption of blood supply to the liver tissue resulted in a size reduction of the tissue.
01:11Cellular Injury IlI: Cellular Death
Cell death is the irreversible loss of cellular structure and function, representing the final stage of severe injury. It plays a key role in both normal physiology and disease.Types of Cell DeathThe two main types are necrosis and apoptosis, though others like necroptosis and pyroptosis also exist.Necrosis:Necrosis is an unregulated form of cell death caused by severe injury such as trauma, toxins, or ischemia. It is characterized by cell swelling, membrane loss, rupture, and leakage of...
01:16Necrosis
Necrosis is considered as an “accidental” or unexpected form of cell death that ends in cell lysis. The first noticeable mention of “necrosis” was in 1859 when Rudolf Virchow used this term to describe advanced tissue breakdown in his compilation titled “Cell Pathology”.
Morphological Manifestations of Necrosis
Necrotic cells show different types of morphological appearance depending on the type of tissue and infection. In coagulative necrosis, cells become anucleated and die, but their...
Morphological Manifestations of Necrosis
Necrotic cells show different types of morphological appearance depending on the type of tissue and infection. In coagulative necrosis, cells become anucleated and die, but their...
01:17Phagocytosis of Apoptotic Cells
Cells undergoing apoptosis form apoptotic bodies that must be removed immediately to prevent inflammation, autoimmune diseases, and necrosis. Phagocytosis is carried out by professional phagocytes such as macrophages or immature dendritic cells. Non-professional phagocytes such as epithelial cells and fibroblasts also take part in this process; however, they are not as effective as professional phagocytes.
Normal cells contain receptors that prevent them from being recognized by phagocytes.
Normal cells contain receptors that prevent them from being recognized by phagocytes.