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Updated: May 20, 2026
Development of Compendium for Esophageal Squamous Cell Carcinoma
Published on: April 12, 2024
Detection and prognostic analysis of serum protein expression in esophageal squamous cell cancer
Hong Jiang1, Xiao-Hong Wang, Xin-Min Yu
1Key Laboratory of Thoracic Tumor Diagnosis(Esophagus, Lung) and Treatment Technology Research, Department of Thoracic Surgery, Zhejiang Cancer Institue, Hangzhou, China.
Objective:
To assess differences in serum proteins in esophageal squamous cell carcinoma patients.
Methods:
144 esophageal squamous cell carcinoma patients and 50 healthy volunteers were included in this study, with surface-enhanced laser desorption-ionization time-of-flight mass spectrometry and weak cation exchange magnetic beads. Follow-up allowed the relations between serum proteins and prognosis to be analyzed.
Results:
A total of 93 protein peaks were detected (molecular weight range: 1500-3000), 10 demonstrating statistically significant differences. There were no differences in protein peaks between 92 patients with a survival more than 2 years and 52 patients with survival less than 2 years. There were two significantly different protein peaks between 45 stage II patients with a survival more than 2 years and 14 stage II patients with survival less than 2 years. There was one significantly different protein peak between 22 stage III patients with a survival more than 2 years and 29 stage III patients with survival less than 2 years.
Conclusion:
Differences of serum proteins in esophageal squamous cell carcinoma are related to prognosis of patients. The protein fingerprint can be helpful for clinical diagnosis and treatment.