Related Experiment Video
Updated: May 20, 2026
12:02
Human Primary Trophoblast Cell Culture Model to Study the Protective Effects of Melatonin Against Hypoxia/reoxygenation-induced Disruption
Published on: July 30, 2016
Experimental study of cytoprotective effect of melatonin in radiation exposure
L V Pikalova1, V I Legeza, M B Ivanov
1S. M. Kirov Military Medical Academy, St. Petersburg, Russia. pikalova_lidiya@mail.ru
Bulletin of Experimental Biology and Medicine
|July 18, 2012
Abstract:
The effects of a synthetic analog of melatonin in doses of 10 and 50 mg/kg on the incidence of chromosome aberrations in bone marrow cells was studied in outbred rats exposed to single short-term γ-irradiation in doses of 2 and 4 Gy. Melatonin injected 30 min before the exposure 2-fold reduced the incidence of chromosome aberrations. Possible mechanisms of anticlastogenic effect of melatonin are discussed.
