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Related Concept Videos

T Cell Types and Functions01:24

T Cell Types and Functions

When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
T Cell Activation and Clonal Selection01:22

T Cell Activation and Clonal Selection

T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...

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Related Experiment Video

Updated: May 20, 2026

Phenotypic and Functional Analysis of Activated Regulatory T Cells Isolated from Chronic Lymphocytic Choriomeningitis Virus-infected Mice
07:17

Phenotypic and Functional Analysis of Activated Regulatory T Cells Isolated from Chronic Lymphocytic Choriomeningitis Virus-infected Mice

Published on: June 22, 2016

[Regulatory T lymphocytes CD4(+): current issues].

Aurélie Siri1, Hubert de Boysson, Guilaine Boursier

  • 1Master Immunotechnologies et biothérapies, université Pierre et Marie Curie, Paris, France. aurelie.siri@hotmail.fr

Medecine Sciences : M/S
|July 19, 2012
PubMed
Summary
This summary is machine-generated.

Regulatory T cells (Treg) are crucial for immune balance, preventing autoimmunity and managing immune responses. This review explores natural and induced Treg, their functions, and mechanisms.

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Generation of Induced Regulatory T Cells from Primary Human Naïve and Memory T Cells

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Related Experiment Videos

Last Updated: May 20, 2026

Phenotypic and Functional Analysis of Activated Regulatory T Cells Isolated from Chronic Lymphocytic Choriomeningitis Virus-infected Mice
07:17

Phenotypic and Functional Analysis of Activated Regulatory T Cells Isolated from Chronic Lymphocytic Choriomeningitis Virus-infected Mice

Published on: June 22, 2016

New Tools to Expand Regulatory T Cells from HIV-1-infected Individuals
09:27

New Tools to Expand Regulatory T Cells from HIV-1-infected Individuals

Published on: May 30, 2013

Generation of Induced Regulatory T Cells from Primary Human Naïve and Memory T Cells
14:23

Generation of Induced Regulatory T Cells from Primary Human Naïve and Memory T Cells

Published on: April 16, 2012

Area of Science:

  • Immunology
  • Cell Biology

Context:

  • Regulatory T cells (Treg) are vital for maintaining peripheral tolerance and preventing autoimmune diseases.
  • Treg cells also regulate immune responses in allergy, transplantation, cancer, and infectious diseases.

Purpose:

  • To review the characterization of Treg cells, including natural and induced populations.
  • To discuss the roles and mechanisms of action of Treg cells in health and disease.
  • To highlight the significance of induced Treg cells.

Summary:

  • Natural Treg cells differentiate in the thymus and express CD4, CD25, and FOXP3.
  • Induced Treg cells are a distinct population with significant roles, characterized recently.
  • This review covers Treg characterization, functions, mechanisms, and the importance of induced Treg.

Impact:

  • Provides a comprehensive overview of regulatory T cell biology.
  • Highlights the dual role of Treg cells in tolerance and immune regulation.
  • Emphasizes the emerging importance of induced Treg cells in immunological research and potential therapeutic strategies.