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Updated: May 20, 2026

Facile Preparation of 4-Substituted Quinazoline Derivatives
Published on: February 15, 2016
2,3-Dichloro-5,8-dimeth-oxy-1,4-naphtho-quinone
Maraizu Ukaegbu1, Ray J Butcher, N M Enwerem
1Department of Chemistry, Howard University, 525 College Street, NW, Washington, DC, 2059 USA.
Abstract:
In the crystal structure of the title compound, C(12)H(8)Cl(2)O(4), mol-ecules crystallize in planes parallel to (-204) with an inter-planar distance of 3.288 (2) Å [centroid-centroid distance = 3.819 (2) and slippage = 1.932 (2) Å]. The structure features C-H⋯O inter-actions involving meth-oxy and aromatic H atoms and the carbonyl O atoms as well as a C-H⋯Cl inter-action involving an aromatic H atom. In addition there are short inter-halogen contacts between adjoining mol-ecules [Cl⋯Cl = 3.3709 (5) Å].
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