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A model of hyperhomocysteine-induced endothelial dysfunction in rats
M V Korokin1, M V Pokrovskiy, O O Novikov
1Kursk State Medical University, Ministry of Health Care and Social Development of the Russian Federation, Russia. mkorokin@mail.ru
Bulletin of Experimental Biology and Medicine
|July 19, 2012
Abstract:
Intragastric methionine (3 g/kg daily for 7 days) elevates homocysteine concentration and increases the endothelial dysfunction coefficient. This protocol of methionine treatment is an adequate model of hyperhomocysteine-induced endothelial dysfunction and can be used for studies of the endothelio- and cardioprotective effects of drugs.
