Related Experiment Video
Updated: May 20, 2026

In Vivo Osteo-organoid Approach for Harvesting Therapeutic Hematopoietic Stem/Progenitor Cells
Published on: February 16, 2024
Effect of regular physical training on hemopoiesis in experimental animals
O T Kudaeva1, O P Kolesnikova, T G Sukhenko
1Institute of Clinical Immunology, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk, Russia. olga_kudaeva@mail.ru
Abstract:
Regular physical activity of moderate intensity over a long period (swimming at water temperature of 33-35°C without load, 2 h per day, 5 days a week for 4 months) activated hemopoiesis in mice: stimulation of myelopoiesis in the bone marrow and increase in the percentage of erythropoietic elements in the spleen were observed. In the peripheral blood, the relative content of lymphocytes increased, that of granulocytes decreased, and plasma cells appeared. Stimulation of erythropoiesis in the spleen can be partially responsible for suppression of immune responses during physical exercise.
Related Concept Videos
Overview of Hematopoiesis
Developmental Phases of Hematopoiesis
Initially, HSCs are formed in the embryonic yolk sac, a critical site for early blood cell production. These stem cells subsequently migrate to other...
Factors Affecting Erythropoiesis
Several factors influence the erythrocyte production rate, with tissue oxygen level being among the most critical. Intense exercise or high altitudes can cause tissue hypoxia, which triggers the kidneys to release more erythropoietin (EPO) into the bloodstream.
EPO then...
Role of Hematopoietic Growth Factors
Thrombopoietin (TPO), mainly released by the liver,...
Hematopoiesis
Regulation of Hematopoietic Stem Cells
Erythropoiesis

