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Updated: May 20, 2026

Constructing Mutants in Serotype 1 Streptococcus pneumoniae strain 519/43
Published on: September 11, 2020
Epidemiology of Streptococcus pneumoniae
1Laboratoire de microbiologie, hôpital Européen Georges-Pompidou, 20, rue Leblanc, 75908 Paris cedex 15, France. emmanuelle.varon@egp.aphp.fr
Public health measures in France reduced antibiotic resistance and invasive pneumococcal infections. However, non-vaccine serotypes increased, though overall infections in young children remain low.
Area of Science:
- Epidemiology
- Infectious Diseases
- Public Health
Background:
- Invasive pneumococcal disease (IPD) epidemiology is influenced by public health interventions.
- France implemented antibiotic stewardship in 2001 and childhood vaccination in 2003.
Purpose of the Study:
- To assess the impact of public health measures on Streptococcus pneumoniae epidemiology in France.
- To evaluate changes in antibiotic resistance and serotype distribution of invasive pneumococcal infections.
Main Methods:
- Observational study analyzing epidemiological data on invasive pneumococcal infections.
- Monitoring of antibiotic resistance patterns in S. pneumoniae strains.
- Tracking of serotype-specific incidence rates before and after interventions.
Main Results:
- A decrease in antibiotic resistance among S. pneumoniae strains was observed.
- Incidence of IPD due to vaccine serotypes declined.
- An increase in IPD caused by non-vaccine serotypes (7F and 19A) was noted.
- Despite serotype replacement, overall IPD incidence in children under 2 years remained below pre-vaccine levels.
Conclusions:
- Public health measures have altered the epidemiology of invasive pneumococcal infections in France.
- While vaccine-induced serotypes decreased, non-vaccine serotypes have emerged as a concern.
- The pneumococcal conjugate vaccine program has successfully reduced overall IPD burden in young children.
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