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Related Concept Videos

Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
Modified-Release Drug Delivery Systems: Site-Targeted01:24

Modified-Release Drug Delivery Systems: Site-Targeted

Site-targeted drug delivery systems enhance therapeutic efficacy while minimizing systemic toxicity and treatment costs. Unlike conventional methods, these systems ensure precise drug delivery, improving bioavailability and reducing side effects. Targeted drug delivery is classified into three levels. First-order targeting directs drugs to the capillary beds of specific organs or tissues. Second-order targets specific cell types, such as tumor cells, using receptor-mediated interactions.
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

Site-Targeted Drug Delivery Systems: Polymeric Carriers

Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
Pharmacogenomics: Identification of New Drug Targets01:29

Pharmacogenomics: Identification of New Drug Targets

Advances in genomics have profoundly influenced drug discovery by increasing both the speed and accuracy of pharmaceutical development. Pharmacogenomics, which examines how genetic variation influences drug response, facilitates the identification of novel therapeutic targets and enables patient stratification for personalized treatment. These strategies contribute to improved drug efficacy, minimized adverse effects, and more efficient clinical trial design.Mapping genetic differences...

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Related Experiment Video

Updated: May 20, 2026

Polymalic Acid-based Nano Biopolymers for Targeting of Multiple Tumor Markers: An Opportunity for Personalized Medicine?
14:20

Polymalic Acid-based Nano Biopolymers for Targeting of Multiple Tumor Markers: An Opportunity for Personalized Medicine?

Published on: June 13, 2014

Personalized nanomedicine.

Twan Lammers1, Larissa Y Rizzo, Gert Storm

  • 1Department of Experimental Molecular Imaging, RWTH Aachen University, Aachen, Germany. tlammers@ukaachen.de

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
|July 26, 2012
PubMed
Summary
This summary is machine-generated.

Personalized medicine uses image-guided nanomedicines to tailor chemotherapy. Noninvasive imaging helps select patients, optimize treatments, and minimize toxicity for better outcomes.

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A Comprehensive Procedure to Evaluate the In Vivo Performance of Cancer Nanomedicines
07:59

A Comprehensive Procedure to Evaluate the In Vivo Performance of Cancer Nanomedicines

Published on: March 4, 2017

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Last Updated: May 20, 2026

Polymalic Acid-based Nano Biopolymers for Targeting of Multiple Tumor Markers: An Opportunity for Personalized Medicine?
14:20

Polymalic Acid-based Nano Biopolymers for Targeting of Multiple Tumor Markers: An Opportunity for Personalized Medicine?

Published on: June 13, 2014

A Comprehensive Procedure to Evaluate the In Vivo Performance of Cancer Nanomedicines
07:59

A Comprehensive Procedure to Evaluate the In Vivo Performance of Cancer Nanomedicines

Published on: March 4, 2017

Area of Science:

  • Oncology
  • Nanomedicine
  • Medical Imaging

Background:

  • Personalized medicine tailors chemotherapy using patient-specific data.
  • Nanomedicines offer targeted drug delivery with integrated imaging capabilities.
  • Current challenges include predicting treatment response and optimizing drug dosage.

Purpose of the Study:

  • To explore the potential of combining noninvasive imaging with nanomedicine for personalized chemotherapy.
  • To demonstrate how imaging can preselect responsive patients and guide treatment optimization.
  • To evaluate the use of imaging in monitoring nanomedicine accumulation in target and healthy tissues.

Main Methods:

  • Development of image-guided nanomedicines containing drugs and imaging agents.
  • Noninvasive visualization of nanomedicine accumulation at target sites.
  • Longitudinal monitoring of patient response to nanomedicine therapy.
  • Assessment of nanomedicine distribution in healthy tissues via imaging.

Main Results:

  • Noninvasive imaging can identify patients likely to respond to nanomedicine interventions.
  • Longitudinal imaging allows for real-time optimization of drug doses and treatment protocols.
  • Imaging can detect nanomedicine accumulation in healthy tissues, enabling patient exclusion from treatment to prevent toxicity.

Conclusions:

  • Combining noninvasive imaging with tumor-targeted nanomedicine delivery is a promising strategy for personalizing chemotherapy.
  • This approach enables precise drug delivery to the right patient at the right time.
  • It holds significant potential for improving therapeutic efficacy and minimizing side effects in cancer treatment.