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Modified-Release Drug Delivery Systems: Stimuli-Activated01:30

Modified-Release Drug Delivery Systems: Stimuli-Activated

Stimuli-activated drug delivery systems are designed to release drugs in response to specific physical, chemical, or biological stimuli. These systems often utilize hydrogels—three-dimensional, hydrophilic polymer networks capable of swelling in aqueous environments and retaining significant fluid volumes. Upon exposure to particular stimuli, these hydrogels undergo structural transitions that allow the embedded drug to be released. Due to this adaptive behavior, such systems are also called...
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Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications
09:39

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Published on: February 7, 2021

Hydrogels in mucosal delivery.

Hamde Nazar1, Marta Roldo, Dimitrios G Fatouros

  • 1School of Pharmacy & Biomedical Sciences, University of Portsmouth, Portsmouth, Hampshire, POI 2DT, UK.

Therapeutic Delivery
|July 28, 2012
PubMed
Summary
This summary is machine-generated.

New hydrogel therapeutics offer enhanced drug delivery on mucosal surfaces. These advanced nanosized systems provide improved residence time and targeted, triggered drug release for better therapeutic outcomes.

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Area of Science:

  • Biomaterials Science
  • Drug Delivery Systems
  • Nanotechnology

Background:

  • Mucoadhesion principles and mucoadhesive agent synthesis are well-established.
  • Hydrogel formulations for mucosal application are readily available.
  • Traditional drug delivery faces limitations in residence time and targeted release.

Purpose of the Study:

  • To introduce next-generation therapeutics utilizing nanosized hydrogel systems.
  • To highlight the potential of bio-recognition and environmental triggers for drug release.
  • To address the need for improved residence time and stimuli-responsive drug delivery on mucosal surfaces.

Main Methods:

  • Development of nanosized hydrogel systems.
  • Incorporation of biological recognition or targeting motifs.
  • Integration of responsiveness to disease-specific environmental triggers and chemical signals.

Main Results:

  • Emerging nanosized hydrogel systems demonstrate potential for advanced therapeutic applications.
  • These systems are designed to react to specific biological and environmental cues.
  • Anticipated benefits include enhanced drug residence time and triggered release.

Conclusions:

  • Nanosized hydrogel systems represent a promising new frontier in mucosal drug delivery.
  • The use of targeting motifs and environmental triggers enables sophisticated therapeutic strategies.
  • These advanced formulations offer improved residence time, faster response, and triggered release capabilities.