[The metabolic predictors of depression under diabetes mellitus]

The possibility to detect the depressive disorders in patients with diabetes mellitus is discussed. The comprehensive analysis was applied to the indicators of carbohydrate metabolism, lipidograms and state of system of lipids peroxidation - antioxidant defense. It is established that the development of clinically valuable medium and severe depression under diabetes mellitus is related to the decrease of level of heptane soluble products of lipids peroxidation (diene conjugate) on the background of increasing of concentration of alpha-tocopherol and total content of cholesterol in blood serum. These biochemical indicators reflected the severity of comorbid depression under diabetes mellitus. They had no dependencies of age and gender diabetes mellitus of patients, duration and type of diabetes mellitus. The most informative predictor was established the level of tokoferolemia. Its registration makes it possible to verify the clinically valuable depression under diabetes mellitus with sensitivity level of 70.5% and specificity level of 64.1%.