Outcomes of regenerative endodontic procedures

Area of Science:

• Endodontics
• Regenerative Medicine
• Dental Traumatology

Background:

• Immature teeth with necrotic pulp pose treatment challenges.
• Regenerative endodontic procedures (REPs) offer a promising therapeutic approach.
• Existing evidence primarily comprises case reports and series.

Purpose of the Study:

• To summarize outcomes of regenerative endodontic techniques in immature necrotic teeth.
• To review radiographic evidence of healing and root development.
• To highlight the current limitations in human histologic data.

Main Methods:

• Review of published case reports and case series on regenerative endodontics.
• Analysis of reported radiographic outcomes, including bone healing, root length, and dentin deposition.
• Identification of studies reporting histologic findings.

Main Results:

• Radiographic evidence indicates successful apical bone healing.
• Significant increases in root length and root wall thickness have been observed.
• Histologic data from human teeth remains largely unavailable, with most evidence from animal models.

Conclusions:

• Regenerative endodontics demonstrates positive radiographic outcomes for immature necrotic teeth.
• Further research, particularly human histologic studies, is needed to fully understand the regenerative process.
• REPs represent a significant advancement in managing complex endodontic cases.