Related Experiment Video
Updated: May 20, 2026
07:12
Establishment of a Simple and Effective Rat Model for Intraoperative Parathyroid Gland Imaging
Published on: August 17, 2022
Papillary thyroid carcinoma associated with parathyroid adenoma
Habibollah Mahmoodzadeh1, Iraj Harirchi, Maryam Hassan Esfehani
1Department of Surgical Oncology, Cancer Institute, Imam Khomeini Hospital Complex,Tehran University of Medical Sciences, Tehran, Iran. dr94habib@yahoo.com
Acta Medica Iranica
|July 28, 2012
Summary
This case report highlights a rare instance of papillary thyroid cancer co-occurring with parathyroid adenoma. Early calcium level checks are recommended for thyroid cancer patients to detect potential hyperparathyroidism.
Area of Science:
- Endocrinology
- Oncology
- Surgical Pathology
Background:
- Concomitant papillary thyroid cancer and parathyroid adenoma represents a rare clinical presentation.
- Primary hyperparathyroidism, often caused by parathyroid adenoma, is characterized by hypercalcemia.
Observation:
- A 55-year-old female presented with papillary thyroid cancer requiring surgical intervention.
- Preoperative assessment revealed hypercalcemia, indicative of primary hyperparathyroidism.
- The patient underwent thyroidectomy, neck dissection, and parathyroid adenoma excision.
Findings:
- Histological examination confirmed the presence of a parathyroid adenoma.
- Post-surgical normalization of serum calcium levels was observed.
- The co-occurrence of these two distinct endocrine conditions was established.
Implications:
- Routine preoperative calcium level screening in patients diagnosed with thyroid cancer is advised.
- This approach may facilitate the early detection and management of concurrent parathyroid pathology.
- Understanding this rare association can improve diagnostic strategies and patient outcomes.
Related Concept Videos
00:59The Parathyroid Glands
The two pairs of parathyroid glands embedded within the posterior surface of the thyroid gland are restricted by a dense capsule around them. These glands comprise two distinct cell populations—parathyroid oxyphil and parathyroid principal cells- pivotal in calcium homeostasis.
Oxyphil cells, whose functions remain elusive, emerge during late puberty, adding a layer of complexity to the parathyroid gland's intricacies. In contrast, principal parathyroid cells undertake a vital role by producing...
Oxyphil cells, whose functions remain elusive, emerge during late puberty, adding a layer of complexity to the parathyroid gland's intricacies. In contrast, principal parathyroid cells undertake a vital role by producing...
01:27Hyperthyroidism II: Pathophysiology
Hyperthyroidism is a hypermetabolic state caused by elevated levels of thyroid hormones, triiodothyronine (T3) and thyroxine (T4). It results from dysregulation at the thyroid, pituitary, or immune system level and affects multiple organ systems.PathophysiologyThe most common cause of hyperthyroidism is Graves’ disease, an autoimmune disorder in which antibodies, specifically thyroid-stimulating antibodies (TSAb), a subtype of TSH receptor antibodies (TRAb), bind to and activate TSH receptors...
01:24Graves Disease II: Pathophysiology
Graves’ disease is an autoimmune disorder characterized by the production of thyroid-stimulating immunoglobulins (TSI) that activate TSH receptors, leading to excessive synthesis and release of thyroid hormones (T3 and T4) and resulting in hyperthyroidism.Among all causes of hyperthyroidism, Graves’ disease is the most common and can happen at any age, though it is more frequent in women. It produces a hypermetabolic state with features such as weight loss, tachycardia, tremor, and heat...
01:25Hyperthyroidism I: Introduction
Hyperthyroidism is a type of thyrotoxicosis characterized by the thyroid gland's overproduction of the thyroid hormones triiodothyronine (T3) and thyroxine (T4). This hormone excess increases the basal metabolic rate and enhances sensitivity to catecholamines.DiagnosisDiagnosis is based on clinical features and biochemical testing. It typically shows suppressed thyroid-stimulating hormone (TSH) levels below 0.4 mIU/L, with elevated free T3 and/or T4. Additional tests, including thyroid...
01:17Hormones and Bone Tissue
The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
00:51Synthesis and Functions of Calcitonin
Calcitonin, a vital polypeptide hormone, regulates calcium levels within body fluids. It is released by the parafollicular cells, also known as C cells, situated in the follicular epithelium of the thyroid gland. Calcitonin responds to fluctuations in blood calcium levels and the influence of gastrointestinal hormones like gastrin and cholecystokinin.
The exact mechanisms by which calcitonin operates in calcium homeostasis remain elusive, but its significance is evident in several vital...
The exact mechanisms by which calcitonin operates in calcium homeostasis remain elusive, but its significance is evident in several vital...