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Chemical-Induced Skin Carcinogenesis Model Using Dimethylbenz[a]Anthracene and 12-O-Tetradecanoyl Phorbol-13-Acetate (DMBA-TPA)
Published on: December 19, 2019
Acetaminophen-induced exanthem of the breasts
1Department of Allergy/Immunology, William Beaumont Army Medical Center, El Paso, Texas 79920, USA. rarora@familyallergy.com
Cutis
|July 31, 2012
Summary
Acetaminophen can cause a rare skin rash called a maculopapular exanthem. This drug eruption appeared in specific areas due to pressure from clothing.
Area of Science:
- Dermatology
- Pharmacology
Background:
- Drug eruptions are common adverse reactions to medications.
- Acetaminophen (paracetamol) is a widely used over-the-counter analgesic and antipyretic.
- Exanthematous drug eruptions are the most frequent type of cutaneous drug reaction.
Observation:
- An unusual case of maculopapular exanthem is presented.
- The rash was secondary to acetaminophen (paracetamol) use.
- The eruption was localized to the breasts and anterior pelvis, corresponding to areas of pressure from undergarments.
Findings:
- This case highlights a specific presentation pattern of acetaminophen-induced exanthematous drug eruption.
- The distribution suggests that localized pressure may influence the site of drug reactions.
- A literature review on acetaminophen-induced exanthematous drug eruptions is included.
Implications:
- Clinicians should consider acetaminophen as a potential cause of maculopapular exanthem, even with unusual distribution patterns.
- The findings may prompt further investigation into pressure-induced drug reactions.
- Awareness of this presentation can aid in earlier diagnosis and management of adverse drug events.
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