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Updated: May 19, 2026
14:39
Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma
Published on: November 4, 2010
A case of uncontrolled asthma.
Allergy & Rhinology (Providence, R.I.)
|August 2, 2012
Summary
Persistent asthma symptoms despite maximal treatment may indicate a carcinoid tumor. This case highlights the importance of investigating underlying causes before initiating new therapies like anti-IgE for severe asthma.
Area of Science:
- Pulmonology
- Thoracic Surgery
- Oncology
Background:
- Severe asthma management can be challenging, with some patients exhibiting persistent symptoms despite optimal therapy.
- Uncontrolled asthma warrants a thorough diagnostic evaluation to exclude alternative pathologies.
Purpose of the Study:
- To report a case of a carcinoid tumor initially presenting as refractory severe asthma.
- To emphasize the need for differential diagnosis in cases of treatment-resistant asthma.
Main Methods:
- A 48-year-old female with severe, uncontrolled asthma underwent evaluation for anti-immunoglobulin E (anti-IgE) therapy.
- Diagnostic workup included chest radiography, fiberoptic bronchoscopy, and computed tomography (CT).
- Surgical resection (left lower lobectomy and lymph node dissection) was performed, followed by pathological examination.
Main Results:
- Imaging revealed an endobronchial lesion obstructing the left lower bronchus.
- Pathological examination confirmed a typical carcinoid tumor.
- Post-surgical resection, the patient's respiratory symptoms resolved completely with no recurrence.
Conclusions:
- A carcinoid tumor can mimic severe, refractory asthma.
- Comprehensive evaluation is crucial for patients with persistent asthma symptoms despite aggressive treatment.
- Surgical intervention can lead to complete symptom resolution and cure in cases of endobronchial carcinoid tumors.
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