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Flow Cytometry

Flow Cytometry

The development of flow cytometry techniques began in 1934 with initial attempts by Andrew Moldavan, a bacteriologist who counted the cells in a flowing capillary system. Moldavan pumped cells through a capillary tube focused under a microscope for visualization. The invention of photometry allowed the measurement of differentially-stained cells, and Louis Kamentsky developed the first multiparameter flow cytometer in 1965 to identify and count the cancer cells in cervical tissue specimens.
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Updated: May 19, 2026

Wide-field Fluorescent Microscopy and Fluorescent Imaging Flow Cytometry on a Cell-phone

Wide-field Fluorescent Microscopy and Fluorescent Imaging Flow Cytometry on a Cell-phone

Published on: April 11, 2013

Optofluidic detection for cellular phenotyping.

Yi-Chung Tung¹, Nien-Tsu Huang, Bo-Ram Oh

¹Research Center for Applied Sciences, Academia Sinica, 128 Sec. 2, Academia Rd. Nankang, Taipei, 11529, Taiwan.

|August 3, 2012

Summary

This summary is machine-generated.

Optofluidics integrates optics and microfluidics for precise cellular phenotyping. This technology advances disease screening and personalized medicine through advanced optical detection methods.

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Last Updated: May 19, 2026

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Fluorescence detection methods for microfluidic droplet platforms

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Microfluidic Imaging Flow Cytometry by Asymmetric-detection Time-stretch Optical Microscopy (ATOM)

Microfluidic Imaging Flow Cytometry by Asymmetric-detection Time-stretch Optical Microscopy (ATOM)

Published on: June 28, 2017

Area of Science:

Biomedical Engineering
Optical Physics
Cell Biology

Background:

Quantitative analysis of cellular processes is crucial for disease screening and personalized medicine.
Optical detection is a widely used method for cellular phenotyping in biological and clinical assays.
Microfluidics offers advantages like small sample volumes, high throughput, and precise flow control.

Purpose of the Study:

To review recent advancements in optofluidic technologies for cellular phenotyping.
To highlight the potential of optofluidics in enabling on-chip phenotypic measurements.
To discuss the integration of optics and microfluidics for enhanced biological analysis.

Main Methods:

Review of recent literature on optofluidic devices and techniques.
Analysis of optofluidic systems for cellular phenotyping applications.
Discussion of optical detection principles within microfluidic platforms.

Main Results:

Optofluidics enables on-chip cellular phenotyping with high precision, sensitivity, specificity, and simplicity.
Integration of optics and microfluidics offers novel approaches for quantitative cellular analysis.
Recent developments show significant promise for advancing disease screening and personalized medicine.

Conclusions:

Optofluidic technologies are rapidly evolving and offer powerful tools for cellular analysis.
The combination of optical detection and microfluidics is key to future advancements in high-throughput, precise cellular phenotyping.
This technology has the potential to revolutionize disease diagnostics and therapeutic strategies.