Hydrogen peroxide and glucose biosensor based on silver nanowires synthesized by polyol process

Area of Science:

• Electrochemistry
• Nanomaterials Science
• Biosensor Technology

Background:

• Development of novel electrode materials is crucial for advancing electrochemical sensor technology.
• Silver nanowires (AgNWs) offer unique electrical and catalytic properties suitable for sensor applications.
• Polyvinylpyrrolidone (PVP) is commonly used to stabilize nanomaterials during synthesis.

Purpose of the Study:

• To synthesize polyvinylpyrrolidone-protected silver nanowires (PVP-AgNWs) for use as an electrode material.
• To evaluate the performance of PVP-AgNWs modified electrodes for hydrogen peroxide (H(2)O(2)) detection.
• To construct and assess a glucose biosensor utilizing PVP-AgNWs for glucose detection in human blood serum.

Main Methods:

• Synthesis of PVP-AgNWs via a polyol process.
• Modification of a glassy carbon electrode (GCE) with PVP-AgNWs (PVP-AgNWs/GCE).
• Electrochemical characterization and performance testing for H(2)O(2) reduction.
• Immobilization of glucose oxidase (GOD) onto the PVP-AgNWs/GCE surface to create a glucose biosensor.

Main Results:

• The PVP-AgNWs/GCE exhibited significant catalytic activity towards H(2)O(2) reduction.
• The H(2)O(2) sensor demonstrated a rapid amperometric response (<2 s) and a wide linear range (20 μM to 3.62 mM) with a low detection limit (2.3 μM).
• The glucose biosensor showed a sensitivity of 15.86 μA mM(-1) cm(-2) and maintained good selectivity and stability for detecting glucose in human blood serum.

Conclusions:

• PVP-AgNWs are effective electrode materials for electrochemical sensing applications.
• The developed H(2)O(2) sensor offers fast response and high sensitivity.
• The PVP-AgNWs-based glucose biosensor shows promise for reliable and selective glucose monitoring in biological samples.