[Alpha-dephenzine concentration in peripheral blood of patients diagnosed with schizophrenia]

Over the past few decades the search for predisposed biological markers has become the course of most priority in scientific psychiatry. Research goal was to reveal the association of alpha-dephenzine concentration in peripheral blood with the disease existence and its progressing (acute and chronic forms) in patients with schizophrenia. In-patients diagnosed with schizophrenia have been investigated (av. age - 45.33±1.86), among them 26 males (av. age - 39.41±1.86) and 13 females (av. age - 45.04±2.44). 27 patients with acute form of schizophrenia (av.age - 44.88±2.42), 12 patients with a chronic form (av. age - 46.33±2.75). 15 healthy volunteers have been investigated as well (av.age - 40.03±2.94), 5 males and 10 females among them. The study of alpha-dephenzine concentration by the immunoenzyme method has been implied in the investigation. Research studies revealed statistically valid increased concentration of alpha-dephenzine in patients diagnosed with schizophrenia comparing with healthy volunteers. The difference was so evident that qualitative difference (marker existence-nonexistence) would rather be considered than quantitative one. Relying on the results of studies we can estimate alpha-dephenzines as possible biomarkers of schizophrenia.