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Updated: Aug 3, 2026
12:23
Granulocyte-dependent Autoantibody-induced Skin Blistering
Published on: October 12, 2012
Contact granuloma anulare
1Department of Contact Allergy and Occupational Dermatitis, Academy of Medicine, Sofia, Bulgaria.
Dermatosen in Beruf Und Umwelt. Occupation and Environment
|September 1, 1990
Summary
Granuloma annulare can be triggered by nickel exposure. A positive patch test confirmed nickel sulfate as the cause in this case.
Area of Science:
- Dermatology
- Allergology
Background:
- Granuloma annulare is a benign inflammatory skin condition.
- Cutaneous reactions to metals are increasingly recognized.
Observation:
- A patient presented with granuloma annulare.
- The condition appeared after direct contact with nickel-containing objects.
Findings:
- Patch testing with 5% nickel sulfate yielded a positive result.
- This confirms nickel as the causative agent for the granuloma annulare.
Implications:
- Highlights the importance of metal patch testing in suspected contact-induced granuloma annulare.
- Suggests nickel allergy as a potential trigger for this specific dermatosis.
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