Related Experiment Video
Updated: May 19, 2026
08:07
Personalized Peptide Arrays for Detection of HLA Alloantibodies in Organ Transplantation
Published on: September 6, 2017
A novel HLA-A31 allele, A*31:22, was identified by sequence-based typing
1Cardiology Department, Sheng Jing Hospital of China Medical University, Shenyang, Liaoning, China.
Tissue Antigens
|August 7, 2012
Summary
A new human leukocyte antigen (HLA) allele, HLA-A*31:22, has been identified. It differs from HLA-A*31:01:02 by a single nucleotide change in exon 2.
Area of Science:
- Immunogenetics
- Molecular biology
Background:
- Human leukocyte antigen (HLA) genes are crucial for immune response.
- Allelic variations within HLA genes contribute to diverse immune capabilities.
Observation:
- A novel HLA allele, designated HLA-A*31:22, was identified.
- This allele exhibits a single nucleotide polymorphism (SNP) at position 245 in exon 2.
Findings:
- The specific nucleotide change identified is an adenine (A) to cytosine (C) substitution.
- HLA-A*31:22 is differentiated from its closest known relative, HLA-A*31:01:02, by this single base pair alteration.
Implications:
- This discovery expands the known allelic diversity of the HLA-A locus.
- Understanding novel HLA alleles is vital for transplantation, disease association studies, and personalized medicine.
Related Concept Videos
02:20Blood Types
Human blood is classified into different types based on the presence of antigens on the red blood cell's surface and antibodies in the plasma. Proper identification of blood type is essential for successful blood transfusion. The International Society of Blood Transfusion has identified 38 human blood types based on the surface antigens on the red blood cells. The most common types are ABO, Rh, and MNS blood types.
ABO blood group
ABO antigens are glycoproteins encoded by genes present on...
ABO blood group
ABO antigens are glycoproteins encoded by genes present on...
01:10Blood Typing
Understanding an individual's blood group is a critical component of transfusion medicine. It ensures compatibility in blood transfusions, organ transplants, and even during pregnancy. Determining these blood groups involves the ABO and Rh blood typing systems, utilizing specific antigens and corresponding anti-sera to identify an individual's blood type.
Antigens are protein molecules that reside on the surface of red blood cells (RBCs). The ABO and Rh blood typing systems target antigens A,...
Antigens are protein molecules that reside on the surface of red blood cells (RBCs). The ABO and Rh blood typing systems target antigens A,...
01:11Genome-wide Association Studies-GWAS
Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
GWAS does not require the identification of the target gene involved in...