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Updated: May 19, 2026
An Advanced Murine Model for Nonalcoholic Steatohepatitis in Association with Type 2 Diabetes
Published on: April 26, 2019
Simulation of nonalcoholic steatohepatitis in rats
Yu K Karaman1, T P Novgorodtseva, T A Gvozdenko
1Vladivostok Affiliated Department of Far Eastern Center of Respiratory Physiology and Pathology, Siberian Division of the Russian Academy of Medical Sciences; Institute of Medical Climatology and Rehabilitative Treatment, Russia. karaman@inbox.ru
Abstract:
The new model of nonalcoholic steatohepatitis in rats is based on alimentary effects of hypercaloric diet including much cholesterol and beef fat. This model reproduces structural and functional disorders in the liver, including hepatocyte fatty degeneration, parenchymatous necrosis and fibrosis paralleled by dyslipidemia and is intended for studies of the mechanisms of formation, progress, and therapy of liver diseases of noninfectious origin.
